- Meeting abstract
- Open Access
1115 Assessment of myocardial T2* from pixel-by-pixel maps on a clinical MR system
© Messroghli et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Pulse Sequence
- Iron Overload
- Short Axis Slice
- Commercial Software Package
- Cardiac Vein
Measurement of myocardial T2* has become an accepted means for the diagnosis and follow-up of myocardial iron overload. The underlying studies were carried out in patients with thalassaemia major presenting with variable degrees of iron overload due to repeat transfusions and in small groups of healthy volunteers; these studies used customized pulse sequences, and T2* was derived from regions-of-interest using a commercial software package.
The aim of our study was to establish normal values of myocardial T2* in a medium-sized cohort of healthy subjects on a standard clinical MR system from pixel-by-pixel maps using a non-commercial software tool.
Evaluable T2* maps could be generated from all data sets (right Fig 1), and computation time was <30 s using a 2.0 GHz processor. Septal T2* (= mean of anteroseptal and inferoseptal segments; right Fig., black arrow heads) was higher than inferolateral T2* (27.9 +/- 3.4 vs. 23.1 +/- 5.2 ms; p < 0.002) and showed a narrower confidence interval of the mean (26.3 to 29.5 ms vs. 20.6 to 25.5, respectively). Liver T2* did not correlate with septal T2* (r = 0.21), but showed a similar normal range (27.2 +/- 5.9 ms, CI of mean 24.3 to 30.2 ms).
This study shows that measurements of myocardial T2* using a product pulse sequence and a free mapping tool are feasible and robust. Myocardial T2* should be assessed in the septum where measurements are less influenced by susceptibility artifacts from the great cardiac vein. Our results from healthy subjects confirm the finding of previous studies from other groups where myocardial T2* below 20 ms was abnormal (95% lower limit in our study: 21.1 ms).
This article is published under license to BioMed Central Ltd.