- Meeting abstract
- Open Access
1121 Increasing the velocity-to-noise ratio in time-resolved 3D blood flow measurements
© von Spiczak et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Phase Noise
- Particle Trace
- Parallel Imaging
- Aortic Annulus
- Phase Unwrap
Time-resolved phase contrast (PC) imaging permits the assessment of volumetric, multi-directional blood flow velocities . The resulting vector field data can be visualized in different ways using streamlines, arrows, and particle traces . These visualization modes allow for an accurate and intuitive analysis of blood flow characteristics in normal and pathological cases . Despite the advantages of the method, wide-spread acceptance in a clinical setting has been hampered by the long scan durations.
In order to reduce the long measurement times, parallel imaging  may be employed. Noise amplification from parallel imaging can partly be compensated for by conducting the measurements at high field. Since the velocity-to-noise ratio (VNR) is not only dependent on base signal-to-noise but also scales inversely with the encoding velocity (Venc), lowering Venc may be considered an alternative approach to improving VNR. If Venc is chosen smaller than the actual blood velocities, phase aliasing arises and needs to be corrected. Phase unwrapping is a well studied field and has been extensively discussed for two  and more dimensions .
It was the objective of the present work to improve VNR by using low Venc phase contrast imaging in conjunction with an automatic phase unwrapping algorithm suited for time-resolved 3D blood flow measurements.
Time-resolved 3D PC data covering the left-ventricular outflow tract, ascending and descending aorta were acquired on a Philips 3 T Achieva system (Philips Medical Systems, Best, The Netherlands). Scan parameters of the navigated and retrospectively triggered fast gradient-echo sequence were: FOV = 320 × 260 × 51 mm3, matrix = 128 × 128 × 17, TR = 3.95/3.85ms, flip angle = 5°, cardiac phases = 25. Healthy subjects were scanned twice with Venc1x, y = 200cm/s, Venc1z = 100cm/s avoiding phase wraps and Venc2x, y = 100cm/s, Venc2z = 50cm/s intentionally accepting phase wraps.
The phase unwrapping algorithm was designed to take into account appropriate prior knowledge about the phase evolution during one heart cycle: a) absence of phase wraps was assumed for the first heart phase; b) phase wraps can only occur between two mate extremes of the first derivative v'(t); and c) the intermediate curvature given by the second derivative v"(t) must fit the remainder of the velocity curve. To correct residual aliases a 5 × 5 median filter was applied, correcting single misjudged voxels with respect to the 2π level of the median.
After unwrapping, the VNR of both the high Venc data series and the unwrapped low Venc series were calculated for regions-of-interests in the ascending aorta. Velocity noise was determined from the phase noise in static tissue as automatically identified using temporal statistics of the velocity data. Both data series were then used to calculate traces for particles interspersed in the aortic arch during mid systole.
It has been shown that lowering the encoding velocity with subsequent phase unwrapping is a feasible method to improve VNR in time-resolved PC. The unwrapping algorithm proposed features linear complexity and high accuracy and is therefore well suited for time-resolved 3D multi-directional velocity data.
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