- Meeting abstract
- Open Access
1125 Spiral first-pass myocardial perfusion imaging at 3 Tesla: feasibility study
© Shin et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Myocardial Perfusion Imaging
- Fast Acquisition
- Accurate Quantitative Analysis
- Channel Cardiac Coil
- Short Spiral
Achieving high spatial resolution and complete coverage of the left ventricle is desirable in first-pass myocardial perfusion imaging (MPI) for robust detection of regional perfusion deficits associated with significant CAD. 2DFT combined with parallel imaging [1, 2] is currently most commonly used for clinical applications since it is relatively robust to inherent errors such as off-resonance and gradient delay. Echo planar imaging also has been used for fast acquisition in MPI , but additional correction for ghosting artifacts is typically required. Another well-known fast acquisition scheme uses spiral trajectories. While spiral MPI has not been reported presumably due to its high sensitivity to off-resonance effects, the approach allows high readout duty cycles and efficient coverage of k-space  providing the rationale for the present study. We applied short spiral readouts with spectral spatial RF pulse to single slice MPI, and obtained high quality images from a healthy subject.
The purpose of the present study was to investigate the feasibility of spiral first-pass MPI at 3 Tesla.
The pulse sequence consists of a BIR4 RF pulse for B1 and B0 insensitive global saturation, and an interleaved spiral gradient echo acquisition. A spectral spatial readout RF pulse is used for fat suppression. The blurring effect caused by off-resonance is a well-known problem in spiral imaging and increases with increasing magnetic field strength (e.g. 3 T). Hence, a short readout time of 4.2 ms was used, and a total of 14 interleaves were combined in a bit reversed order for a target in-plane resolution of 2 × 2 mm2 and FOV of 26 × 26 cm2. Other imaging parameters included: TR = 9.8 ms, flip angle = 30°, and slice thickness = 8 mm. Imaging used ECG-gating such that a single diastolic cardiac phase could be acquired with each cardiac cycle.
The spiral perfusion sequence was tested on a healthy volunteer using a GE Signa Excite whole body 3 T scanner with an 8 channel cardiac coil. Gd-DTPA (Magnevist, 0.1 mmol/kg) was injected at 3 ml/sec followed by 20 ml of saline, and the subject was instructed to hold his breath as long as possible.
We have demonstrated the feasibility of spiral MPI at 3 Tesla that can provide high spatial resolution with minimal blurring effects.
This article is published under license to BioMed Central Ltd.