- Meeting abstract
- Open Access
125 Characterization of infarct heterogeneity by fuzzy clustering
© Detsky et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Ventricular Tachycardia
- Fuzzy Cluster
- Inversion Time
- Infarct Core
- Healthy Myocardium
Infarcted tissue interspersed with surviving bundles of myocytes can cause ventricular arrhythmias via the reentry phenomena. Infarct heterogeneity as assessed by delayed-enhancement MRI (DE-MRI) has been shown to correlate with inducibility for ventricular tachycardia (VT) . However, the separation of the infarct core from the periphery (or "gray zone") using conventional DE-MRI images relies on an arbitrary selection of a signal intensity (SI) cut-off. DE-MRI images generally have a low SNR; therefore, noise may influence the size of the gray zone. Recently, a new method using an inversion-recovery SSFP (IR-SSFP) sequence has been described to produce multiple infarct-enhanced images at various inversion times .
In this work a new method for assessing infarct heterogeneity based on parameterization and fuzzy clustering of IR-SSFP images was developed.
Fuzzy clustering applied to IR-SSFP images can be used to classify pixels as infarct core, infarct grey zone, healthy myocardium and blood. Future work is needed to determine if heterogeneity measured by this method is predictive of VT, and to compare this method to the SI threshold method using conventional DE-MRI images.
- Schmidt A: Circ. 2007, 115: 2006-14. 10.1161/CIRCULATIONAHA.106.653568.View ArticleGoogle Scholar
- Detsky JS: Magn Reson Med. 2007, 58: 365-72. 10.1002/mrm.21291.View ArticlePubMedGoogle Scholar
- Schmitt P: Magn Reson Med. 2004, 51: 661-7. 10.1002/mrm.20058.View ArticlePubMedGoogle Scholar
- Gustafson DE: Proc of IEEE CDC. 1979, 761-6.Google Scholar
This article is published under license to BioMed Central Ltd.