1137 Single-shot, dark-blood, T2-weighted, inversion-recovery CMR with spin echo – echo planar umaging (DB-STIR EPI)
© Giri et al; licensee BioMed Central Ltd. 2008
Published: 22 October 2008
Acute myocardial infarction and other causes of myocardial edema are best visualized by dark blood STIR-TSE turbo spin echo (DB-STIR TSE) [1, 2]. However, this segmented technique is sensitive to arrhythmia and respiratory motion. Single-shot dark blood HASTE (DB-STIR HASTE) eliminates the need for patient breath-hold, but the longer echo train further increases sensitivity to cardiac motion, which can lead to myocardial signal dropout . Single-shot SSFP based techniques have been proposed , but the bright blood pool may affect endocardial border depiction, and the lack of STIR contrast has yet to be evaluated. We propose a single-shot dark-blood STIR prepared spin-echo echo-planar imaging (DB-STIR EPI) sequence with parallel acquisition technique (PAT) to reduce sensitivity to cardiac motion.
To develop a single-shot DB-STIR EPI technique for edema imaging of the heart, and compare its soft tissue contrast and sensitivity to cardiac motion to DB-STIR HASTE in healthy volunteers.
A single shot spin echo EPI sequence was developed on a 1.5 T clinical system (Avanto, Siemens Medical Solutions, Erlangen) incorporating dark blood and slice selective inversion preparation pulses. The coil sensitivity map required for GRAPPA PAT was acquired in a separate heart-beat to minimize echo train length.
3 healthy volunteers gave informed consent to participate in this IRB-approved study. The subjects were scanned to optimize sequence parameters and compare the contrast and motion sensitivity of DB-STIR EPI with DB-STIR HASTE. (Table 1). The high fluid content of spleen gives it a significantly longer T1 and T2 than liver; therefore liver-spleen contrast was used to visually evaluate the sensitivity of each sequence to tissue fluid. Sensitivity to cardiac motion was investigated by testing each sequence at 2 different trigger delays (TD). The TD was first optimized for uniform myocardial signal intensity for each patient, and then adjusted by -50 msec to shift the acquisition window to an earlier period of diastole with greater cardiac motion.
Imaging sequence parameters.
Temporal Resolution (msec)
300 × 400
300 × 400
Image Matrix (pixels)
108 × 192
116 × 192
DB-STIR EPI generated single-shot fat-suppressed images with similar contrast to DB-STIR HASTE, but with less sensitivity to cardiac motion. Additional studies are needed to investigate the sensitivity of this technique to myocardial edema.
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