2001 Effects on myocardial perfusion at 3 and 15 months in recanalized chronic total occlusions – randomized comparison of blood-derived progenitor cells and inactive serum
© Thiele et al; licensee BioMed Central Ltd. 2008
Published: 22 October 2008
MRI is an excellent diagnostic tool for serial assessment of changes in myocardial perfusion, left ventricular function, and infarct size. In chronic total occlusions (CTO) the effects of recanalization on perfusion and function are contradictory and might depend primarily on viability. Circulating progenitor cells (CPC) injected intracoronarily after successful CTO recanalization might improve perfusion and function.
To assess, if CPC improve perfusion and subsequently infarct size and left ventricular function in comparison to control.
Methods and results
Analysis of serial contrast-enhanced MRI suggests that intracoronary application of CPC post recanalization of CTO is associated with improved myocardial perfusion and subsequent improved recovery of left ventricular function as compared to a control group at mid- and long-term follow-up. Further investigations of the pathophysiological CPC effects on macro- and microvascular function are required.
This article is published under license to BioMed Central Ltd.