- Meeting abstract
- Open Access
2026 Tradeoffs between spatial coverage and dynamic temporal resolution in quantitative first-pass perfusion imaging
© Hsu et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Myocardial Perfusion
- Myocardial Blood Flow
- Stress Myocardial Blood Flow
- Myocardial Blood Flow Estimate
- Peak Contrast Enhancement
First-pass contrast-enhanced perfusion MRI is a useful tool for the diagnosis of ischemic cardiac disease. Quantitative analysis of myocardial perfusion depends on measuring dynamic signal intensity changes of the LV blood and myocardium as a function of time. There is an inverse relationship between the number of slices imaged per unit time and the repetition time for those spatial locations. For example, a perfusion sequence that can image 3 slices per heartbeat could image 6 locations every other heartbeat.
The purpose of this study was to show that high temporal sampling of the input function is important for perfusion quantification, but the myocardial sampling rate may be reduced and still achieve highly accurate measures of perfusion.
Dual-bolus (Gd-DTPA 0.005 and 0.1 mmol/kg) rest and dipyridamole stress myocardial perfusion MR imaging was performed on 10 normal volunteers on a 1.5 T Siemens scanner. Each perfusion study was acquired in a breath-hold and with single RR imaging interval. A segmented GRE-EPI sequence was used by the following parameters: 90° prep, 25° readout, TR 7.5 ms, TE 1.48 ms, 8 mm slice thickness, echo train length 4, acquisition matrix 128 × 80–96, FOV 360 × 270 mm. Time-signal intensity curves of the perfusion images were analyzed by dividing the myocardium into 6 sectors. Myocardial blood flow (MBF) was estimated from LV input and myocardial output time-signal intensity curves by a Fermi model constrained deconvolution. Using MBF quantified from LV and myocardial curves at 1RR temporal resolution as a reference standard, we compared MBF estimated from 2RR and 3RR under-sampled time-signal intensity curves.
Comparison of myocardial blood flow (MBF) estimates from under-sampled time-signal intensity.
MBF (ml/g/min) Mean ± SD
0.95 ± 0.22
1.02 ± 0.21
1.27 ± 0.73
1.01 ± 0.34
0.89 ± 0.33
3.34 ± 0.72
3.11 ± 0.81
3.20 ± 0.74
2.88 ± 0.84
2.71 ± 0.76
Reduced temporal sampling of the LV blood signal intensity during myocardial perfusion imaging significantly affects myocardial blood flow estimates. Under-sampling the LV input curve to 2RR or 3RR intervals results in systematic underestimation of MBF and increased scatter of the errors. Since reduced temporal sampling of the time-signal intensity curves theoretically acts as a low pass temporal filter which suppresses dynamic contrast information, the effects are more significant for LV blood than the myocardial curves and are larger for stress than rest perfusions. However, combining 1RR temporal resolution in the LV and 2RR temporal resolution in the myocardium during perfusion imaging has minimal impact to MBF estimates and could effectively double the spatial coverage without sacrificing the accuracy of quantitative perfusion measures.
This article is published under license to BioMed Central Ltd.