- Meeting abstract
- Open Access
131 Arterial spin labeled myocardial perfusion imaging with background suppression: initial results
© Zun et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Myocardial Perfusion
- Myocardial Perfusion Imaging
- Myocardial Blood Flow
- Arterial Spin Label
- Background Suppression
The use of arterial spin labeling (ASL) for assessing myocardial perfusion has several advantages over existing techniques. ASL does not rely on contrast agents, can achieve arbitrarily high resolution, and is naturally quantitative. ASL is widely used for assessing cerebral blood flow. However, its application to myocardial blood flow has been limited [1, 2]. Current subtractive methods suffer from artifacts stemming from high LV blood signal including Gibbs ringing and mis-registration. In this work, we investigate the use of background suppression (BGS) [3, 4] in the context of ASL cardiac perfusion imaging using flow-sensitive alternating inversion recovery (FAIR) .
Background suppression is expected to reduce the effects of mis-registration and ringing in subtractive ASL imaging. The spatially varying BGS is likely due to B1+ inhomegeneity. Despite the use of adiabatic pulses, simulations (not shown) indicate that B1+ variation can lead to a small spatially varying signal residue. Current results have limited SNR, and would benefit from signal averaging using multiple breath-holds or respiratory navigation (work in progress). Improved BGS may eventually allow for non-subtractive ASL.
- An J, et al: ISMRM. 2005, 253-Google Scholar
- Zhang H, et al: MRM. 2005, 53 (5): 1135-1142.View ArticlePubMedGoogle Scholar
- Ye FQ, et al: MRM. 2000, 44 (1): 92-100.View ArticlePubMedGoogle Scholar
- Duyn JH, et al: MRM. 2001, 46: 88-94.View ArticlePubMedGoogle Scholar
- Kim SG, et al: MRM. 1995, 34: 293-301.View ArticlePubMedGoogle Scholar
- Noeske R, et al: MRM. 2000, 44: 978-982.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.