- Meeting abstract
- Open Access
2085 Strain encoded magnetic resonance imaging (SENC) assessment of regional ventricular function in pulmonary arterial hypertension – initial results
© Shehata et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Right Ventricular
- Pulmonary Arterial Hypertension
- Right Ventricular Dysfunction
- Myocardial Scar
- Pulmonary Arterial Hypertension Patient
Evaluation of right ventricular (RV) function is an important prognostic factor in many cardiac and/or pulmonary conditions. Pulmonary arterial hypertension (PAH) is a major cause of RV dysfunction and failure, which in turn affects left ventricular performance due to ventricular interdependence. Cardiac MRI is a reproducible three dimensional tomographic tool providing accurate measurements of global right ventricular function. For the RV, measuring regional strain using MRI (e.g., using tagging) is limited by thin wall. Strain encoded MRI (SENC), however, enables the quantification of RV strain (1) in the longitudinal direction (Ell), which is the main contributor to RV contractile function. On the other hand, fast strain encoded MRI (fSENC) allows for single heartbeat, non breath hold, acquisitions; thus providing an alternative to patients experiencing difficulty in breath holding (2).
To analyze the effect of pulmonary arterial hypertension on myocardial strain using strain encoded MRI.
Healthy volunteers were imaged using 13 sec breath hold SENC acquisition (TR = 22 msec, TE = 0.8 msec, flip angle = 40°, FOV = 350 × 350 mm at a spatial resolution of 3 × 3 mm). Fast SENC (fSENC) acquisition (TR = 32 msec, TE = 0.8 msec, flip angle = 40°, FOV = 150 × 150 mm and spatial resolution of 4 × 4 mm) was used to scan patients with catheterization established diagnosis of PAH (mean ± SD pulmonary artery pressure [PAP] = 34.25 ± 10.6 mm Hg). Both groups were scanned at 3 T MRI. Three short-axis slices at the base, mid and apical regions were acquired for each subject. Image analysis was performed using custom software. Left ventricular Ell was quantified from six basal, six mid and four apical regions respectively. Ell in the RV free wall was measured at 5 equidistant segments starting from the anterior septal insertion and ending at the posterior septal insertion. At each segment, two measurements of Ell were averaged to calculate peak systolic Ell, defined from cine SENC and fSENC images as strain values at peak contraction. In our analysis, we excluded two suboptimal apical slices from volunteer group as well as two anterior right ventricular segments from patient group passing through RV out flow tract plane. Peak systolic Ell values of the LV and RV regions in patients were compared to corresponding regions in control group using unpaired Student-t test.
This article is published under license to BioMed Central Ltd.