- Meeting abstract
- Open Access
2090 Right ventricular involvement in reperfused myocardial infarction: an experimental DE-MRI study using inversion recovery prepared SSFP
© Yang et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Acute Myocardial Infarction
- Acute Myocardial Infarction
- Reperfused Myocardial Infarction
- Ventricular Branch
- Right Ventricular Myocardial Infarction
Right ventricular myocardial infarction (RV-MI) and dysfunction have been shown as independent indicators of poor prognosis in patients with acute myocardial infarction (AMI) [1, 2]. Diagnosis of RV-MI is usually made by the presence of an ST-segment elevation of 0.1 mV in the V3R or V4R of the ECG and/or abnormal RV free wall motion on echocardiography. DE-MRI using IR-FGRE (inversion recovery fast gradient echo) has been used to detect the RV involvement in AMI, but its sensitivity and specificity is limited by the thinned wall and confounded by the pericardial fat tissue. We hypothesize that an inversion recovery steady state free precession (IR-SSFP) pulse sequence with the multiple-contrast imaging capability is a better method for the identification of RV-MI.
To investigate an IR-SSFP based DE-MRI sequence in the detection of RV-MI in a porcine model with reperfused MI.
In eight Yorkshire pigs (22–30 kg) a reperfused MI was produced through a 90-minute percutaneous balloon occlusion of the left anterior descending coronary artery proximal to the right ventricular branch. After reperfusion and full recovery from anesthesia, animals were allowed to survive for six weeks (n = 7) and one week (n = 1).
The MR study, which included an SSFP functional study, conventional IR-FGRE based, and IR-SSFP based DE-MRI, was conducted on a GE 1.5 T Signa Excite system. Both IR-FGRE and IR-SSFP were performed 15–20 minutes after double-dose bolus injection of Gd-DTPA. For IR-FGRE, TI varied from 150 to 300 ms, depending on the null of normal myocardium. For IR-SSFP, the SSFP is applied during IR, which means that the longitudinal magnetization is sampled during the transition process from T1 recovery to its true steady-state . For both IR-FGRE and IR-SSFP based DE-MR, the in-plane resolution was around 1 mm*1 mm. Short-axis oblique and/or axial transverse slices were obtained using both pulse sequences. Upon the completion of MRI examinations all animals were sacrificed for macroscopic examination, TTC staining and/or histology for the verification of RV-MI and LV-MI.
Inversion-recovery SSFP based DE-MRI is a better technique for the identification of RV involvement in an experimental model of reperfused myocardial infarction. Further clinical investigation is warranted for the true utility of this technique in the identification of RV myocardial infarction.
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