- Meeting abstract
- Open Access
2127 Validation of cardiovascular magnetic resonance aortic distensibility with applanation tonometry pulse wave velocity
© Nelson et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Cardiovascular Magnetic Resonance
- Arterial Stiffness
- Pulse Wave Velocity
- Young Cohort
- Steady State Free Precession
Arterial stiffness has been shown to be an independent predictor of adverse cardiovascular events. Applanation tonometry (TONO) evaluation of pulse wave velocity (PWV) is widely accepted as the 'gold standard' method of non-invasively assessing arterial stiffness. Newer non-invasive tools such as cardiovascular magnetic resonance (CMR) have the capability to evaluate arterial stiffness, but to date have not been formally evaluated against TONO.
The aim of this study was to validate CMR derived aortic distensibility with the non-invasive 'gold standard' TONO PWV as a method of assessing arterial stiffness.
A strong correlation between aortic distensibility and TONO PWV was observed at all three levels of the aorta (all p < 0.01). Interestingly the strength of the quadratic regression was greater than for the simple non-transformed linear regression highlighting a curvilinear relationship between these two variables. The coefficients of determination for AA, PDA and DDA were R2 = 0.531, 0.508 and 0.805 respectively. After inverse and squaring transformations the coefficients of determination were R2 = 0.381, 0.306 and 0.878.
As expected the old cohort had a significant increase in arterial stiffness compared to the young cohort. A Bonferroni post-hoc comparison showed an increase in proximal stiffness in the old cohort compared to the young cohort (p = 0.023).
CMR derived aortic distensibility is an accurate measure of arterial stiffness and can evaluate regional stiffness across different levels of the aorta. This process may preferentially occur in the proximal aortic segments in the elderly providing possible mechanistic links to left ventricular hypertrophy, isolated systolic hypertension and impaired coronary artery perfusion.
This article is published under license to BioMed Central Ltd.