- Meeting abstract
- Open Access
103 Non-invasive measurement of coronary artery flow velocity at rest and during handgrip stress in healthy subjects using 3 T MRI
© Hays et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Right Coronary Artery
- Coronary Flow Velocity Reserve
- Coronary Flow Velocity
- Isometric Handgrip
- Sufficient Image Quality
Endothelial-dependent coronary artery vasoreactivity is an important indicator of vascular function and predicts cardiovascular events . In response to endothelial-dependent stressors, changes in coronary artery cross-sectional area and flow velocity occur which are typically assessed by invasive methods. Magnetic resonance flow mapping is non-invasive and validated for endothelial-independent stressors in humans by comparison with Doppler guidewire measurements [2, 3]. One prior study , performed at 1.5 T and recording 7–11 cine frames per cardiac cycle, assessed coronary flow velocity during isometric handgrip exercise, a well-established provocateur of endothelial-dependent vasoreactivity . As higher magnetic field strengths offer the potential for enhanced temporal and/or spatial resolution, which would support both improved image quality due to reduced blurring and more accurate quantification of diastolic peak velocity, we studied diastolic coronary flow peak velocity with 3 T MRI using spiral acquisitions. Here we describe reactive changes in coronary flow velocity using isometric handgrip exercise in healthy subjects as detected by spiral 3 T MRI with a temporal resolution of 34 ms and an in plane resolution of 0.8 × 0.8 mm.
3 T spiral MRI enables the quantification of coronary flow velocity changes in response to endothelial-dependent stress with both high temporal (34 ms) and spatial resolutions. In healthy adults, isometric handgrip causes significant changes in peak diastolic coronary flow velocity that occur early (30 sec) and do not change further during the ensuing three minutes. Coronary flow velocity returns to baseline only 1 min after the cessation of handgrip. The present findings warrant further studies using this technique in patients at high risk for coronary artery disease and those with suspected endothelial dysfunction.
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