- Meeting abstract
- Open Access
2138 Early atherosclerosis in the carotid and coronary territories: a cardiovascular magnetic resonance and multidetector computed tomography analysis
© Greenwell et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Cardiovascular Magnetic Resonance
- Coronary Artery Calcium
- Framingham Risk Score
- Atheroma Volume
- Maximal Wall Thickness
Framingham risk score (FRS), carotid intima-media thickness (IMT) and coronary artery calcium scoring (CAC) are indicators of atherosclerotic disease and predictors of cardiovascular events. However these techniques have technical and practical limitations; ultrasound-based carotid IMT is operator-dependent and assesses only vessel wall segments while coronary calcification is not reliably associated with atheroma burden in early disease. High-resolution carotid artery cardiovascular magnetic resonance (CMR) has intrinsic benefits that offer the potential to assesses the entire vessel wall, more accurately reflecting underlying changes.
Our objectives were to assess the reproducibility of novel markers of carotid atherosclerosis using CMR and to determine their relationship with existing markers of cardiovascular risk.
Mean FRS was 10.8 ± 8.2%. MRI indices (VWA, maxWT, PAV) were significantly associated with IMT (r = 0.569, r = 0.588, r = 0.575; all P < 0.001), but not with CAC. VWA and maxWT, but not PAV were associated with FRS (r = 0.254, P = 0.004; r = 0.255, P = 0.011). Intra-observer and inter-observer %CV for MRI indices were 2.9% and 3.8% respectively.
Our novel carotid indices are highly reproducible and significantly associated with established indicators of carotid atheroma and cardiovascular risk (IMT and FRS). The lack of association with CAC may reflect a disproportionate relationship between the degree of calcification and atheroma in the carotid and coronary arteries. Follow-up of this cohort for cardiovascular outcomes data is likely to provide more direct information about risk, which will add to our understanding of atherosclerosis at different arterial sites and the role of CMR in predicting cardiovascular events.
This article is published under license to BioMed Central Ltd.