- Meeting abstract
- Open Access
2139 Evaluation of chronic aortopathies using non-contrast enhanced MRA: in consideration of nephrogenic systemic fibrosis
© Agarwal et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Aortic Arch
- Thoracic Aorta
- Aortic Root
- Nephrogenic Systemic Fibrosis
- Aortic Valve Leaflet
Evaluation of chronic aortopathies requires repeated follow-up imaging studies to assess stability. MRI/MRA routinely has been used as the imaging modality of choice for its multiple advantages over competing modalities. However, recently there is heightened concern over gadolinium-enhanced MRA in patients with significant renal insufficiency as a result of nephrogenic systemic fibrosis (NSF). Development of a robust non-gadolinium enhanced MRI/MRA technique is needed for evaluation of aortopathies, particularly in patients with renal insufficiency.
A robust 3D SSFP non-gadolinium enhanced MRA technique is equivalent or superior to traditional 3D gadolinium enhanced MRA.
Qualitative assessment scores for 3D MRA techniques.
Non-Gadolinium Enhanced MRA
Gadolinium Enhanced MRA
Descending Thoracic Aorta
Time (Minutes, Overall)
Time (Minutes, Last 15 Studies)
Non-gadolinium enhanced MRA allows for comprehensive evaluation of aortopathies with a single sequence. Compared to Gad MRA, nonGad MRA is an equivalent technique for quantitative measurement and a superior technique for qualitative evaluation of the aortic root and ascending thoracic aorta. Thorough and accurate evaluations of the aortic root and ascending thoracic aorta (extent of dissection, involvement of coronary arteries, and aortic valve leaflets) are critical and affect clinical management (surgical vs medical intervention). Qualitative evaluation was particularly improved for the aortic root and ascending segment as a result of ECG-gating inherent within the nonGad sequence minimizing motion artifacts to which gadolinium-enhanced images were prone. Theoretically, sternal wires pose problems due to susceptibility artifacts; however, our study results indicate the superiority of nonGad MRA technique even in patients with sternal wires. The 3D nonGad sequence alleviates concerns about NSF and may be a preferred sequence for patients with renal insufficiency and clinical concern for aortopathies. In summary, 3D non-gadolinium enhanced MRA is a robust technique that provides equivalent or superior information on aortopathies compared to standard gadolinium enhanced MRA.
This article is published under license to BioMed Central Ltd.