- Meeting abstract
- Open Access
50 Myocardial signal behaviors of balanced SSFP imaging at 3 T
© Sung and Nayak; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Myocardial Signal
- Balance Steady State Free Precession
- Balance Steady State
- Balance SSFP
- Fiesta Sequence
Balanced steady state free precession (bSSFP) imaging has an established role in the CMR assessment of ventricular function and wall motion . However, measured bSSFP signals do not always agree with simple theoretical predictions. More accurate signal models would enable optimization of imaging parameters (e.g. prescribed flip angle and TR) in order to maximize signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). In this work, we examine the effects of (A) non-ideal slice profile, (B) off-resonance, and (C) radiofrequency transmit (B1+) variation, to identify a model that accurately predicts myocardial signal behavior in bSSFP, over the range of imaging parameters routinely used at 3 T.
Experiments were performed on two 3 T GE EXCITE HD systems in five healthy volunteers. Cardiac bSSFP cine loops were acquired using a product 2D FIESTA sequence with prescribed flip-angles from 10° to 90° with 5° increments. The TR and RF pulse duration were fixed, and the imaging flip angle was adjusted by manually changing the RF pulse amplitude. Imaging parameters: FOV = 30 cm, matrix = 224 × 224, slice = 5 mm, 10 cardiac phases, 20 views per segment, TR = 5.0 ms (4 subjects) or 5.9 ms (1 subject due to SAR constraints). RF pulse: duration = 1.28 ms, time-bandwidth product = 2. Off-resonance maps were acquired in a single breath-hold using a cardiac-gated sequence with two different echo times (TEs). The TE difference was set to 2 ms resulting in a frequency range of ± 250 Hz. B1+ maps were acquired in a single breath-hold using the cardiac-gated saturated double angle method . Images from mid-diastole were selected for analysis, and regions of interest containing septal myocardium were manually selected.
The steady-state signal from static tissue in bSSFP can be expressed as:
SNR ∝ sinα/((T1/T2+1)-cosα·(T1/T2-1)).
Three additional factors were considered: (A) the slice profile α(z) is not ideal, (B) the spins include a range of resonance offsets, and (C) the actual flip angle is not the prescribed flip angle. There are seven possible models that either consider or ignore each factor. All combinations and the conventional method (ignoring all three) were evaluated using a relative error metric defined as:
RelativeError = E(|SI measured -SI expected |/|SI measured |).
Simulations assumed myocardial relaxation times of T1 = 1115 ms and T2 = 41 ms . Bloch simulation and image analysis were performed in MATLAB. It is worth noting that magnetization transfer effects  were not considered in this study.
Accurate myocardial signal prediction can facilitate optimization of SNR and CNR in bSSFP, by guiding the selection of the imaging flip angle and RF pulse. The relative error between measured and theoretically predicted myocardial signal was reduced by 85% by considering three practical factors: non-ideal slice profile, off-resonance, and B1+ inhomogeneity.
This article is published under license to BioMed Central Ltd.