- Meeting abstract
- Open Access
154 Aortic pulse wave velocity assessed with velocity-encoded MRI: a validation and reproducibility study
© Grotenhuis et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Aortic Arch
- Pulse Wave Velocity
- Aortic Pulse Wave Velocity
- Velocity Sensitivity
- Cordis Corporation
Aortic Pulse Wave Velocity (PWV) is a surrogate marker for arterial wall compliance and is defined as the propagation speed of the systolic blood pressure wave through the aorta. PWV is a powerful predictor of all-cause and cardiovascular mortality in various patient groups. PWV can be acquired invasively during catheterization. Although accurate, this method is not well suited for screening or follow-up.
Validation of PWV acquired non-invasively with Velocity-Encoded (VE) MRI by comparison to invasive pressure measurements during catheterization. Also, reproducibility of PWV assessment with MRI is tested.
In 18 patients selected for diagnostic catheterization, pressure measurements were acquired during pullback using a 6 F pressure tip catheter (Cordis Corporation, Miami Lakes, FL, USA). Pressure waves were recorded in the ascending aorta, DA just after AA and in DA proximal to the abdominal bifurcation. The distance between these sites was determined from the catheter pullback. The arrival time of the systolic pressure waves was determined from the minimal blood pressure, just before the rise in pressure.
Eight healthy volunteers were selected to test the reproducibility of PWV assessment with MRI. Subjects were scanned twice on the same day, and once one week later. PWVAA and PWVDA were determined on all occasions and compared for reproducibility.
Reproducibility for PWV acquired with MRI on the same day was high: r = 0.93 for PWVAA; r = 0.53 for PWVDA with no statistically significant bias (difference 0.2 m/s for PWVAA; 0.2 m/s for PWVDA). Coefficient of variation was 11% for PWVAA and 14% for PWVDA. Physiological variation in PWV was higher: r = 0.57 for PWVAA; r = 0.51 for PWVDA with no significant bias (difference 0.1 m/s for PWVAA; 0.1 m/s for PWVDA) and coefficient of variation 20% for PWVAA and 18% for PWVDA.
Non-invasive acquisition of aortic PWV with VE MRI shows good agreement with invasive pressure measurements and can be determined accurately and reproducibly within the limits of the physiological variations.
This article is published under license to BioMed Central Ltd.