- Meeting abstract
- Open Access
156 Pulmonary vein imaging by 3D non-contrast, free breathing SSFP MR angiography; a novel technique
© Singhal et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Pulmonary Vein
- Nephrogenic Systemic Fibrosis
- Free Breathing
- Inferior Pulmonary Vein
- Contrast Enhance Magnetic Resonance Angiography
Radiofrequency ablation of foci in pulmonary veins has emerged as a therapeutic option for patients with medically refractory atrial fibrillation or those unable to tolerate drugs. Preprocedural imaging is important and is being increasingly utilized to assess pulmonary venous anatomy. Contrast enhanced Magnetic Resonance Angiography (CEMRA) has been shown to be an efficient modality for assessment of pulmonary veins with excellent spatial resolution without any exposure to radiation and iodinated contrast. However, CE-MRA is operator dependant and requires patient cooperation for breath holding. Additionally, high dose gadolinium use has been recently reported to be associated with the occurrence of Nephrogenic Systemic Fibrosis (NSF) in certain patients including renal disease patients. Recently, three dimensional navigator gated free breathing selective steady-state free precession (SSFP) sequence has been employed to display non-contrast MR angiography of the heart and great vessels. The SSFP causes inherent high contrast between the blood pool and background tissues in the body due to high T2/T1 ratio.
To investigate the feasibility of non-contrast 3D SSFP MR Angiography for evaluation of pulmonary veins and to correlate the results with conventional contrast-enhanced MRA (CE-MRA).
Twenty consecutive patients (age range 30–81) with known atrial fibrillation underwent free-breathing ECG-gated non-contrast SSFP MRA with non-selective radiofrequency excitation and conventional high-resolution 3D CEMRA of thorax at 1.5 T. Two readers evaluated both datasets for vein definition (from 0, not visualized to 3, excellent definition), artifacts, findings, and intra-vascular signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in the pulmonary veins. Pulmonary vein ostial measurements were also made in both the datasets. Statistical analysis was performed using Wilcoxon test, paired t-test, and kappa co-efficient.
Our results demonstrate that non-contrast 3D SSFP MRA provides sufficient vascular definition and SNR and CNR for confident evaluation of pulmonary veins. This technique may be an alternative approach to CE-MRA especially in patients at increased risk for developing contrast-related complications and those with difficulty in breath holding.
This article is published under license to BioMed Central Ltd.