- Meeting abstract
- Open Access
105 Weight loss reverses aortic distensibility changes in subjects with severe uncomplicated obesity. a one year follow up study
© Rider et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Abdominal Aorta
- Proximal Region
- Significant Weight Loss
- Proximal Segment
Obesity has been linked to reduced aortic elastic function but studies of central aortic distensibility in obesity are limited. Our hypothesis was that aortic distensibility changes in severe obesity are at least partially reversible over one year following significant weight loss.
Fifty subjects (37 uncomplicated obese BMI 38.4 ± 7.2, 14 normal weight BMI 21.9 ± 1.8), all with no identifiable cardiac risk factors, underwent MR imaging of the aorta at 1.5 T. Aortic distensibility was assessed at three levels; the ascending (Ao) and proximal descending aorta (PDA) at the level of the pulmonary artery and the abdominal aorta (AA) The abdominal cine images were piloted perpendicular to the orientation of the abdominal aorta. All subjects were recruited on the basis of no identifiable cardiac risk factors. There were no significant differences in fasting glucose (5.2 ± 0.6 vs 4.9 ± 0.4 mmol/L, p = 0.10), cholesterol (5.0 ± 0.8 vs 5.3 ± 0.9 mmol/L, p = 0.27), systolic blood pressure (122 ± 13 vs 115 ± 10 mmHg, p = 0.10) or diastolic blood pressure (76 ± 8 vs 73 ± 8 mmHg, p = 0.09) between obese and normal weight subjects, with all measurements remaining in the normal range.
Using regional MRI measurements of the aorta, significant reductions in regional mechanical function have been shown in obese individuals in the absence of hypertension, hypercholesterolaemia or diabetes when compared to lean age, sex matched controls. The pattern of this reduction shows a relatively greater reduction in compliance and distensibility in more distal (proximal descending and abdominal) segments of the aorta as opposed to the more proximal segment (ascending aorta). Thus, in uncomplicated obesity, aortic elastic properties are improved after one year of weight loss. Distal aortic elastic function appears to be more sensitive to changes in BMI than more proximal regions.
This article is published under license to BioMed Central Ltd.