- Meeting abstract
- Open Access
204 Magnetic resonance imaging findings in early arrhythmogenic right ventricular dysplasia
© Jain et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Left Ventricular Volume
- Magnetic Resonance Imaging Abnormality
- Arrhythmogenic Right Ventricular Dysplasia
- Magnetic Resonance Imaging Diagnosis
- Task Force Criterion
Magnetic resonance (MR) imaging is readily applied for the diagnosis of advanced structural abnormalities associated with arrhythmogenic right ventricular dysplasia (ARVD). However, the earliest morphologic or functional abnormalties in ARVD on MR imaging have not been previously described.
To describe MRI findings in phenotypically confirmed cases of ARVD with negative or borderline MRI diagnosis.
The Multidisciplinary Study of Right Ventricular Dysplasia aims to characterize the clinical and genetic aspects of ARVD. As of September 2007, 87 newly diagnosed probands were enrolled and phenotyped as affected following the results of invasive and non-invasive tests and based on the task force criteria. MRI was performed in 73 patients (84%) according to a standard protocol at enrollment. During enrollment the MRI was anonymized and interpreted by the core lab in a blinded fashion and categorized as affected, unaffected or borderline. Phenotyping was performed by the PI based on the results of invasive and non-invasive evaluation. Following the final phenotype, MR images of ARVD probands that were initially classified as borderline or unaffected by the corelab were reanalyzed to determine early structural alterations in ARVD. Patients with borderline or unaffected MR imaging diagnosis were compared with patients with definite MR imaging diagnosis of ARVD using Student's unpaired t-test.
Delayed and dyssynchronous contraction of the RV basal free wall is frequently seen in patients with ARVD who otherwise lack major global and regional contraction abnormalities. This finding may represent an earliest phenotypic expression of ARVD on MR imaging.
This article is published under license to BioMed Central Ltd.