Skip to content


  • Meeting abstract
  • Open Access

219 Feasibility of whole-heart steady-state free precession magnetic resonance coronary angiography (MRCA) in infants and children with congenital heart disease

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance200810 (Suppl 1) :A80

  • Published:


  • Coronary Artery
  • Congenital Heart Disease
  • Kawasaki Disease
  • Coronary Segment
  • Left Main


The whole-heart Steady-State Free Precession (SSFP) MRCA has been used in adult patients for imaging coronary tree1. However, its routine use to image coronary arteries in children with congenital heart disease has not been proven yet. Since an abnormal course of coronary arteries is not uncommon in complex congenital heart and relevant for surgical planning.


This study demonstrates the capability of this technique in imaging the origin and course of coronary arteries in children with complex congenital heart disease.


100 patients (median age 3 years, age range 4 months–11 yrs) with congenital heart disease were imaged with Philips Intera 1.5 T MR scanner under general anesthesia. After injection of contrast (Magnevist 0.2 mmol/kg), a vector cardiogram-triggered, free-breathing, 3D-SSFP whole-heart approach with navigator gating (3 mm) was used with nearly isotropic image resolution (table 1). The acquisition window was adapted to the resting period of the heart. Image quality of the left and right coronary arteries were assessed by two independent observers using a score ranging from 0 (nonvisible) to 4 (excellent quality). The coronary arteries were reformatted using Soap-Bubble tool2 for vessel length measurements.

Table 1

Relevant parameters using in whole-heart SSFP MRCA



Repetition time (msec)

4.7 – 5.1

Echo time (msec)


Field of view (mm)

240 – 310

Flip angle (degree)




Slice thickness (mm)

1.0 – 1.3

Number of slices

70 – 130

Voxel size (mm)

1.0 × 1.0 × 1.0 – 1.3 × 1.3 × 1.3

Acquisition window (msec)

40 – 70

Echocardiography findings and surgical findings were reference standards for assessment of coronary origins and proximal course.


All studies were completed without adverse effects. The origins of both left and right coronary arteries were imaged in 89 patients (89%). Only one coronary artery was imaged in 8 patients and 3 patients (age 4 months and 5 months old) were not able to visualized the coronary arteries. Average image quality of left main, left anterior descending, left circumflex and right coronary arteries are described in table 2. Left circumflex artery showed lowest image quality compared with other coronary segments. 9 patients with single coronary artery were correctly detected from MRCA compared to echocardiography findings.
Table 2

Image quality score and vessel length in each coronary segment

Coronary artery segments

Image quality score

Vessel length(mm.)

1. LMT

2.94 ± 1.20

8.4 ± 4.7

2. LAD

2.69 ± 1.24

28.8 ± 17.4

3. LCX

1.77 ± 1.34*^\

17.9 ± 16.2

4. RCA

2.78 ± 1.42

49.2 ± 25.0

LMT indicates left main trunk coronary artery, LAD indicates left anterior descending coronary artery, LCX indicates left circumflex coronary artery, RCA indicates right coronary artery. * indicates statistically significant (p < 0.001) different from LMT. ^indicates statistically significant (p < 0.001) different from LAD. \ indicates statistically significant (p < 0.001) different from LCX.


Using this technique we were able to delineate the coronary artery anatomy in 97% of children with congenital heart disease with the youngest being 4 months old. Abnormal origin and course of the coronary arteries were clearly demonstrated in 9 cases. Further application may include diagnoses of abnormal size, origin and course of the coronary arteries in with Kawasaki disease.
Figure 1
Figure 1

Soap-bubble reconstructed the left coronary system in 10 month old patient.

Figure 2
Figure 2

Soap-bubble reconstructed reconstructed from right coronary MRCA in 6 months patient with post-Norwood I operation.

Authors’ Affiliations

King's College London, London, UK


  1. Weber OM, Martin AJ, Higgins CB: Whole-heart steady state free precession coronary artery magnetic resonance angiography. Magn Reson Med. 2003, 50: 1223-8. 10.1002/mrm.10653.View ArticlePubMedGoogle Scholar
  2. Etienne A, Botnar RM, Van Muiswinkel AM, Boesiger P, Manning WJ, Stuber M: "Soap-Bubble" visualization and quantitative analysis of 3D coronary magnetic resonance angiograms. Magn Reson Med. 2002, 48: 658-66. 10.1002/mrm.10253.View ArticlePubMedGoogle Scholar


© Tangcharoen et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.