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234 A novel in vivo marker for ischemic tissue injury early after coronary occlusion

Background

Early identification of acute myocardial ischemia is a diagnostic challenge. We aimed at identifying the earliest time point at which T2-weighted cardiovascular magnetic resonance imaging could visually identify acute ischemia.

Methods

We studied seven dogs with serial T2-weighted and cine imaging at baseline, during and early after transient coronary occlusion (25–35 minutes) in a 1.5 T MRI system. Late gadolinium enhancement was used to assess irreversible injury.

Results

28 ± 4 minutes after experimental coronary artery occlusion, we observed a transmural area of high T2 signal intensity (contrast to noise ratio to remote myocardium 11.0 ± 10; p < 0.0001), matching areas with new onset regional wall motion abnormalities. Late enhancement imaging performed after reperfusion did not show irreversible injury in any of the dogs (Figure 1).

Figure 1
figure1

We aimed at identifying the earliest time point at which T2-weighted imaging visually identifies acute ischemia in a dog model(n = 7). T2 imaging detected ischemia 28 ± 4 minutes after coronary occlusion before the onset of irreversible damage as identified by late gadolinium enhancement.

Conclusion

We provide the first preliminary evidence that T2-weighted CMR imaging represents a novel in vivo marker for ischemic tissue injury likely before the onset of irreversible injury. T2-weighted CMR may offer a novel potential means of identifying acute ischemia in acute coronary syndromes.

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Correspondence to Hassan Abdel-Aty.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abdel-Aty, H., Cocker, M., Tyberg, J.V. et al. 234 A novel in vivo marker for ischemic tissue injury early after coronary occlusion. J Cardiovasc Magn Reson 10, A95 (2008). https://doi.org/10.1186/1532-429X-10-S1-A95

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Keywords

  • Cardiovascular Magnetic Resonance
  • Late Gadolinium Enhancement
  • Coronary Occlusion
  • Acute Ischemia
  • Regional Wall Motion Abnormality