- Meeting abstract
- Open Access
235 Simultaneous myocardial first-pass perfusion and strain imaging with DENSE
© Le et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Lower Temporal Resolution
- Encode Direction
- Deformable Registration
- Cavity Blood
- Microsphere Flow
We describe a new sequence capable of measuring both perfusion and myocardial strain using DENSE  in a single scan. The images possess dark-blood contrast and upon infusion of Gd-DTPA, ischemic areas remain bright while normal areas become dark. The phase maps of the same images provide displacement and strain maps, which facilitates the correlation of function and perfusion. This technique should enhance the diagnostic value of time-limited stress tests.
The scan lasted 3 – 4 minutes during which the contrast was given. Due to T1 relaxation between displacement-encoding and slice acquisition (200 to 400 ms for the 3 perfusion slices), normal myocardium became dark upon Gd infusion while the ischemic region remained bright. Perfusion and strain were measured in the other 3 slices. All images were registered with deformable registration to remove respiratory motion. Pixel-wise perfusion maps were obtained with Marquardt-Levenberg fitting using the Fermi transfer function . Circumferential strain maps were obtained from each set of 3 encoding directions , and then averaged over the 30 sets.
To our knowledge this approach is unique because of the positive contrast unlike conventional saturation-recovery imaging, and therefore may not have the associated artifacts such as dark rims. A limitation is the lower temporal resolution needed for spin recovery. However, at 3 ml/sec injection rate this did not affect the perfusion measurements in this study. Future work will include comparison with microsphere flow measurements.
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