- Oral presentation
- Open Access
Phase-sensitive black-blood coronary vessel wall imaging
© Abd-Elmoniem and Stuber; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Right Coronary Artery
- Coronary Artery Vessel
- Vessel Wall Imaging
- Wall Thickness Measurement
- Image Data Collection
Black-blood coronary vessel wall imaging is a powerful non-invasive tool for the quantitative assessment of positive arterial remodeling . Although dual-inversion-recovery  (DIR) is the gold standard for vessel wall imaging, optimal lumen-vessel wall contrast is sometimes difficult to obtain and the time-window available for imaging is limited due to the competing requirements between TI* (blood signal nulling time) and TD (period of minimal myocardial motion). In addition, atherosclerosis is a spatially heterogeneous disease and therefore imaging at multiple anatomical levels of the coronary circulation is mandatory. However, this requirement of enhanced volumetric coverage typically comes at the expense of increased scanning time. Phase-sensitive IR [3–5] (PS-IR) has shown to be valuable for enhancing tissue-tissue contrast and for making IR imaging less sensitive to TI*. This work extends PS-IR to PS-DIR and combined with spiral-imaging, multi-slice black-blood coronary vessel wall imaging is enabled in a single breath-hold.
To develop, and test a phase-sensitive DIR (PS-DIR) single-breath-hold multi-slice spiral black-blood coronary vessel wall imaging method.
A single breathhold DIR sequence was implemented (Fig. 1) on a clinical 3 T Philips-Achieva MRI-system. Data were acquired using a segmented k-space spiral acquisition with spectral spatial excitation . Image processing was performed off-line on a personal computer.
Anatomical slices perpendicular to the proximal part of the right coronary artery (RCA) at end-systole were planned similar to a previously published methodology . First, serial single-slice multi-phase PS-DIR images were acquired with incremental TI ranging from 50 ms–500 ms in 15 healthy adult subjects (slice-thickness = 8 mm, FOV = 190 × 190 mm, matrix = 320 × 320, interleaves = 20, acq.window = 18 ms/interleaf). CNR was calculated on the signed-magnitude images reconstructed with the above algorithm. Mean vessel wall thickness was measured manually on the images obtained with incremental TI and was compared to that from TI*. Finally, a dual-slice rather than a multi-phase version of the sequence (Fig. 1) was tested in four subjects.
PS-DIR provides a TI-insensitive higher CNR alternative to conventional DIR for coronary vessel wall imaging. TI-insensitivity can be traded for enhanced volumetric coverage at no extra-cost in imaging time.
- Kim WY, et al: Circulation. 2002, 106 (3): 296-9. 10.1161/01.CIR.0000025629.85631.1E.View ArticlePubMedGoogle Scholar
- Edelman RR, et al: Radiology. 1991, 181 (3): 655-60.View ArticlePubMedGoogle Scholar
- Borrello JA, et al: Magn Reson Med. 1990, 14 (1): 56-67. 10.1002/mrm.1910140107.View ArticlePubMedGoogle Scholar
- Xiang QS: J Magn Reson Imaging. 1996, 6 (5): 775-82. 10.1002/jmri.1880060511.View ArticlePubMedGoogle Scholar
- Kellman P, et al: Magn Reson Med. 2002, 47 (2): 372-383. 10.1002/mrm.10051.PubMed CentralView ArticlePubMedGoogle Scholar
- Meyer CH, et al: Magn Reson Med. 1990, 15 (2): 287-304. 10.1002/mrm.1910150211.View ArticlePubMedGoogle Scholar
- Botnar RM, et al: Circulation. 2000, 102(102)21: 2582-7.View ArticleGoogle Scholar
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