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k-t SENSE accelerated stress myocardial perfusion MRI at 3 Tesla
Journal of Cardiovascular Magnetic Resonance volume 11, Article number: O35 (2009)
The purpose of this study was to evaluate the feasibility and diagnostic accuracy of high spatial resolution stress myocardial perfusion MRI acquired at every heartbeat by using k-t SENSE and 3 Tesla MR imager.
High spatial and temporal resolutions are required for the accurate assessment of myocardial ischemia using stress perfusion MRI.
Thirty-three patients with suspected coronary artery disease were studied. High spatial resolution (<2 mm) first-pass contrast enhanced MR images were obtained at rest and during stress by using a 3.0 T MR imager (Achieva) and k-t SENSE acceleration factor of 5. Saturation recovery TFE images were acquired with TR/TE of 2.9 ms/1.5 ms, FOV = 40 × 30 cm, matrix = 256 × 192, slice thickness = 8 mm. Three short-axis sections of the left ventricle were imaged at every heart beat. Two observers determined the image quality score (1:poor – 4:excellent) and recorded the presence or absence of respiratory artifacts and endocardial dark rim artifacts using a 16-segment model.
All studies were successfully completed, with the averaged image quality score of 3.8 ± 0.4. Endocardial dark rim artifacts were observed in 17 (3.2%) of 528 segments, but there were no cases in which dark-rim artifacts influenced the diagnosis. Respiratory artifacts were found in 11 (2.1%) of 528 segments. In 14 patients who underwent coronary angiography within 2 weeks from MR study, stress-rest perfusion MRI demonstrated the sensitivity, specificity, positive and negative predictive values and accuracy of were 90.9%(10/11), 96.7%(30/31), 90.9%(10/11), 96.7%(30/31) and 95.2%(40/42) for detecting significant coronary artery disease. Figures 1 and 2.
Perfusion MR images with high spatial resolution can be acquired at every heart beat by using a 3 T MR imager and k-t SENSE acceleration. This approach can substantially reduce endocardial dark rim artifacts and allows for an accurate detection of myocardial ischemia in patients with flow-limiting coronary artery disease.
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Kato, S., Sakuma, H., Nagata, M. et al. k-t SENSE accelerated stress myocardial perfusion MRI at 3 Tesla. J Cardiovasc Magn Reson 11, O35 (2009). https://doi.org/10.1186/1532-429X-11-S1-O35
- High Spatial Resolution
- Heart Beat
- Significant Coronary Artery Disease
- Suspected Coronary Artery Disease
- Image Quality Score