Mt Everest trek causes impaired cardiac high energy phosphate metabolism and diastolic impairment
© Holloway et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
Cardiac function in normal subjects is altered by exposure to hypobaric hypoxia, yet the cellular mechanisms leading to such changes are unknown. We have examined the impact of sustained exposure to environmental hypobaric hypoxia, on cardiac function and energetics.
Methods and results
Exposure to prolonged hypobaric hypoxia is associated with significant, but reversible, energetic and functional abnormalities in the human heart.
This article is published under license to BioMed Central Ltd.