- Oral presentation
- Open Access
Delayed hyper-enhancement cardiac magnetic resonance imaging is more accurate than other noninvasive parameters in diagnosis of patients with endomyocardial biopsy positive cardiac amyloidosis
© Austin et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Left Atrial
- Endomyocardial Biopsy
- Cardiac Amyloidosis
- Myocardial Performance Index
- York Heart Association Class
We sought to determine the diagnostic accuracy of DHE-CMR, as compared to standard noninvasive parameters, in patients with suspected CA that underwent EMB.
A total of 38 patients (mean age 62 ± 14 years, 71% men, 57% with New York Heart Association class > 2) with suspected CA underwent electrocardiography (ECG), TTE (including tissue Doppler), DHE-CMR (Siemens 1.5 T scanner, Erlangen, Germany) and EMB between 1/05 and 4/08. Low voltage on ECG was defined as sum of S wave in lead V1 + R wave in lead V5 or V6 < 15 mm. Measured TTE parameters included left atrial size, interventricular septal thickness, speckled appearance, E/A ratio, E/E' ratio, stage of diastology, deceleration time (msec) and myocardial performance index [(isovolumic contraction time + isovolumic relaxation time)/ejection time]. DHE-MR images were obtained in standard long and short axis orientations (covering the entire LV), after injection of Gadolinium dimenglumine using an inversion recovery spoiled gradient echo sequence: TE 4 msec, TR 8 msec, flip angle 30°, bandwidth 140 Hz/pixel, 23 k-space lines acquired every other RR-interval, field of view (varied from 228–330 in the x-direction and 260–330 in the y-direction) and matrix size (varied from 140–180 in the x-direction and 256 in the y-direction). CMR was considered positive in the presence of DHE of entire subendocardium with extension into the neighboring myocardium.
Logistic univariate regression analysis testing the association between endomyocardial biopsy proven cardiac amyloidosis and various noninvasive imaging parameters
Noninvasive imaging parameters
Wald χ2 Statistic
Wald χ2 Statistic
Carroll' Criteria on ECG
Rahman's Criteria on ECG
Dilated left atrium (> 20 cm2)
Interventricular septal thickness
Left ventricular ejection fraction
Speckled appearance on surface echocardiography
Pseudonormal or restrictive physiology on Doppler echocardiography
E/E' ratio ≥ 15
Abnormal deceleration time (≤ 150 msec)
Myocardial performance index
Positive delayed hyper-enhancement cardiac magnetic resonance
DHE-CMR is highly accurate in noninvasive diagnosis of EMB-positive CA as compared to standard ECG and TTE criteria. Incremental prognostic value of DHE-CMR in CA for clinical outcomes needs to be determined.
This article is published under license to BioMed Central Ltd.