Right ventricular dysfunction and injury following marathon running: correlating biomarkers with cardiac MRI
© Mousavi et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
Although previous studies including endurance athletes following marathon running have demonstrated biochemical evidence of cardiac injury and have correlated these findings with echocardiographic evidence of cardiac dysfunction, in particular the right ventricle, a study of marathon athletes incorporating biomarkers, echocardiography and cardiac MRI (CMR) has not been performed to date.
To demonstrate the cardiac changes associated with participation in a marathon using serial cardiac biomarkers, echocardiography and CMR.
Right ventricular systolic dysfunction transiently occurs post marathon, and has been validated for the first time by CMR. The increase in cardiac troponin following marathon running is due to cytosolic release of the biomarker, and not due to true breakdown of the myocyte as confirmed by delayed enhancement CMR.
This article is published under license to BioMed Central Ltd.