- Oral presentation
- Open Access
Controlling ventricular preload using an MRI-compatible lower body negative pressure chamber: measuring changes in volumes, mechanical and hemodynamic function
© Thompson et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Pressure Chamber
- Lower Body Negative Pressure
- Central Blood Volume
- Gold Standard Measure
- Ventricular Preload
Cardiac output is dependent, in part, on the ability of LV to accept preload at low filling pressure. Systematic modulation of preload is thus an important capability for the study of the preload dependence of any given aspect of cardiac performance in health and disease. Previously, LV (un)loading has been studied by control of lower body pressure, used to modulated central blood volume, primarily in conjunction with echocardiographic or invasive measures of LV volumes and systolic function[1–3]. MRI offers the gold standard measures of LV volumes and a growing number of functional parameters based on tissue and blood dynamics, but has not previously been used in conjunction with lower body pressure control. Using a low-cost custom-made MRI-compatible lower body pressure chamber we illustrate controllable preload modulation of LV volumes and mechanical and hemodynamic functional parameters (several of which have not previously been measured with variable preload).
MRI-Compatible Pressure Chamber
Heart rate and volumes and function
Peak Untwisting Rate (deg/sec)
Radial Velocity (cm/s)**
Circumferential Strain rate (s-1)**
We have shown that a simple MRI-compatible lower body pressure chamber can significantly unload the LV and that a comprehensive systolic and diastolic function study is feasible during this unloading (45 minute study duration for both atmospheric and -30 mmHg unloading). Our changes in EDV and SV and standard measures of early filling (E, A and E') are comparable to previous echocardiography unloading studies[1–3] and we report significantly larger decreases in pressure gradients than previous studies. To our knowledge, this is the first report of the unloading dependence of torsion (which is shown to increase with unloading), untwisting rate and radial and circumferential parameters. The superior quantitative functional imaging capabilities of MRI in combination with variable loading conditions enabled by the lower body pressure control will allow detailed physiological studies in controls and any patient group that can be studied using MRI.
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