- Oral presentation
- Open Access
Internal Flow Fraction discriminates patients with dyssynchronous heart failure from age and sex-matched controls
© Fornwalt et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Cardiac Resynchronization Therapy
- Internal Flow
- Mechanical Dyssynchrony
- Left Ventricle Ejection Fraction
- Left Ventricular Dyssynchrony
Evaluate the ability of Internal Flow Fraction to diagnose left ventricular dyssynchrony using standard cine MRI.
Better methods to quantify mechanical dyssynchrony in the heart may improve patient selection for cardiac resynchronization therapy. Dyssynchrony creates inefficient "sloshing" of blood volume internally within the left ventricle (LV). This "internal flow" represents wasted energy due to the dyssynchronous motion of the LV walls. We developed a new method to quantify internal flow from cine cardiac MRI which may provide a better, more physiologic measure of dyssynchrony than existing methods.
LV internal flow will be significantly increased in patients with dyssynchronous heart failure compared to healthy, age and sex-matched volunteers.
Left ventricular Internal Flow Fraction can be quantified from images acquired in a standard cine cardiac MRI exam. Internal flow during the isovolumic periods is a normal, physiologic component of left ventricular contraction and relaxation. A left ventricular Internal Flow Fraction of 4% discriminated patients with dyssynchronous heart failure from age and sex-matched healthy controls with 95% accuracy.
This article is published under license to BioMed Central Ltd.