- Poster presentation
- Open Access
Right ventricular function and structure: results from the Multi-Ethnic Study of Atherosclerosis
© Chahal et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Right Ventricle
- Pearson Coefficient
- Systolic Volume
- Traditional Cardiovascular Risk Factor
- Left Ventricle Mass
Recent studies of right ventricle (RV) structure and function have recognized the critical role of the RV in maintaining cardiac function. Previous studies on the RV have been limited by sample size and inadequate inclusion of participants from different races. The Multi-Ethnic Study of Atherosclerosis (MESA) is a large ongoing multi-center study that aims to investigate the subclinical progression of cardiovascular disease in an ethnically diverse clinically asymptomatic population.
Traditional cardiovascular risk factors have been extensively studied in relationship to the left ventricle (LV). MRI has not been previously used to determine if the RV is independent of these traditional risk factors. The purpose of this study was to assess the relationships of traditional cardiovascular risk factors to RV morphology and function and their relationship to the LV.
Cardiac MRIs were performed on 5,004 participants without clinical cardiovascular disease at six field centers. 1572 randomly selected participants had complete interpretation of RV measures (46% men, mean age 61 ± 10 years). Endocardial margins of the RV were manually contoured on diastolic and systolic images. End-diastolic volume (EDV) and end-systolic volume (ESV) were calculated by using a summation of disks method ("Simpson's Rule"). Baseline variables included demographics and cardiac risk factors. Multivariate linear regression was performed for RV parameters versus traditional cardiovascular risk factors after adjusting for socio-demographic parameters. To evaluate intra-reader and inter-reader variability, 10% of the scans were selected randomly as re-reads (5% intra-reader and 5% inter-reader). Intra-class correlation coefficients (ICC) and Pearson coefficients were used to describe the reproducibility in RV measures.
Age, gender and BMI were related to RV mass and volumes. Other than blood pressure, traditional cardiovascular risk factors (diabetes mellitus, smoking, alcohol consumption, LDL cholesterol) had little relationship to RV mass and volume in the MESA cohort.
This article is published under license to BioMed Central Ltd.