- Poster presentation
- Open Access
Whole heart 3 D MR coronary angiography with and without extracellular contrast agent
© Piotrowska-Kownacka et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Contrast Injection
- Improve Image Quality
- Microvascular Obstruction
- Acute Myocarditis
- Extracellular Contrast Agent
It is well known that extravascular contrast administration before whole heart 3 D MR angiography improves image quality and distal coronary segments visibility. In opposite to extravascular, extracellular contrast agents are commonly used in cardiac MR. The influence on coronary angiography quality remains unknown.
The aim of the study was quality assessment of coronary MR angiography performed after extracellular contrast administration (Gd-DTPA) in stable, consecutive patients referred to CMR lab for contrast enhanced cardiac examination in comparison to unenhanced coronary MR angiography in healthy volunteers.
69 patients and 16 volunteers were examined in 1.5 T scanner with 3D navigator gated, inversion recovery, segmented gradient echo sequence. For data acquisition 32 Channel Cardiac Coil was used. In all patients MR angiography was the last sequence applied. In all patients extracellular contrast agent (Gd-DTPA, 0.1 mmol/kg b.w.) was injected. The time between contrast injection and whole heart MR angiography was monitored. The images were analyzed on MMWP Workstation. Quality of MR angiography was evaluated using 4 point scale: 1-poor, 2-sufficient, 3-good, 4-very good. General image quality and visibility of coronary artery disease: left main, proximal and distal parts of LAD, Cx, RCA were evaluated separately. Differences between unenhanced and enhanced data were analyzed using Mann-Whitney test. P value of below 0,05 was considered statistically significant.
Mean time between contrast injection and sequence start was 12,8 ± 7,7 min. Mean acquisition time was 14 ± 5,9. The median quality score was 3. General MR angiography quality was good or very good in 76,6% of patient and 67,7% of volunteers. There was significant improvement of general quality as well as coronaries visibility in all evaluated arteries and parts on enhanced images. No relation between contrast injection time as well as acquisition time and image quality were found. Enhanced images have given additional information regarding viability in patients with acute myocarditis and viability/no-reflow regions in patients early after myocardial infarction.
This article is published under license to BioMed Central Ltd.