Volume 11 Supplement 1
Circumferential and radial myocardial strain in cardiomyopathy patients with and without left bundle branch block
© Han et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
Electrical dyssynchrony associated with prolonged QRS duration is a commonly used criterion to select symptomatic heart failure patients for cardiac resynchronization therapy (CRT). However, there is concern that electrical dyssynchrony criterion is inadequate as 30–40% of patients do not respond to CRT . Studies have shown that assessment of mechanical dyssynchrony may be a better predictor of response . Most of the studies have assessed mechanical dyssynchrony in the longitudinal axis of myocardial motion . There is limited data on the assessment of short axis mechanical dyssynchrony in humans. We sought to examine the relationship between electrical and mechanical dyssynchrony in mid-ventricular short axis using CMR tagging in patients with depressed left ventricular function.
22 patients with NYHA class II to III heart failure were studied, including 12 patients with dilated cardiomyopathy (DCM) (age 60 ± 9 years, 83% male, ejection fraction (EF) 28 ± 9%) and 10 patients with ischemic cardiomyopathy (ICM) (age 63 ± 8 years, 80% male, EF 30 ± 5%). Ten healthy adult subjects (age 37 ± 12 years, 50% male, EF 60 ± 4%) served as controls. CMR studies were performed on a 1.5 T Philips Achieva MR scanner (Philips HealthCare, Best, NL), equipped with a 5-element cardiac coil. Breath-hold ECG-gated tagged CSPAMM cine images at the mid-papillary muscle level were obtained. Scan parameters include spiral readout with 8 interleaves, 9 ms acquisition window, TR/TE/flip angle = 25 ms/3.6 ms/25°, FOV = 320 mm, 10 mm slice thickness with 5 mm tag spacing, temporal resolution 25–35 ms, spatial resolution 2.5 × 2.5 × 10 mm. A customized software program (Cardiotool), written in MATLAB (MathWorks, Natick, MA), was used for semi-automated analysis of peak circumferential (εc) and peak radial strain (εr) .
In patients with heart failure, a LBBB pattern with marked increase in QRS duration manifests as a specific contractile pattern with marked dyskinesis of the interventricular septum. Mechanical dyssynchrony and reduction in myocardial circumferential and radial strain are identified and quantified using a semi-automated method. This study identifies the relationship between electrical and mechanical circumferential and radial dyssynchrony in patients with dilated as well as ischemic cardiomyopathy.
- Yu CM, Fung JWH, Zhang Q, et al: J Cardiovasc Electrophysiol. 2005, 16: 1117-1124. 10.1111/j.1540-8167.2005.40829.x.View ArticlePubMedGoogle Scholar
- Nelson GS, Curry CW, Wyman BT, et al: Circulation. 2000, 101: 2703-2709.View ArticlePubMedGoogle Scholar
- Yu CM, Chau E, Sanderson JE, et al: Circulation. 2002, 105: 438-445. 10.1161/hc0402.102623.View ArticlePubMedGoogle Scholar
- Haber I, Metaxas DN, Axel L: Med Image Anal. 2000, 4: 335-55. 10.1016/S1361-8415(00)00028-1.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.