Assessment of change in aortic distensibility in patients with left ventricular hypertrophy (LVH), before and after therapy, using Cardiac Magnetic Resonance (CMR) imaging
© Negrou et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
To determine whether two aggressive antihypertensive treatment strategies with opposing mechanistic effects, but the same effect on arterial blood pressure (BP) control, had different influences on aortic distensibility.
Alteration in the structure and function of the aortic wall and its elastic properties are important in the pathogenesis of cardiovascular disease , and are associated with aging and diabetes mellitus. These changes can cause a decrease in aortic distensibility (AD) and as a consequence elevated pulse pressure . This increased aortic stiffness can be a predictor of hypertension and may be both a cause and effect of sustained high BP . Studies to date of antihypertensive therapy have been conflicting with regard to whether there is a treatment specific effect.
Thirty-four age matched patients (mean age = 56 ± 11.6; 32–77 yrs) were randomly divided into two groups. All patients were hypertensive, non-diabetic and had CMR confirmed left ventricular hypertrophy (LVH). Both groups underwent treatment for 6 months; the first group (Group VM) was treated with Valsartan and Moxonidine and the second group (Group BA) with Bendroflumethiazide and Amlodipine. A third group (Group N) consisting of normal volunteers (15 volunteers; mean age = 49 ± 10.5; 29–63 years) was used as control. Both treatment groups (VM and BA) were scanned using cine-MRI (SSFP, transverse to the aorta, 24 phases; Philips 1.5 T Gyroscan Intera CV) before and after therapy. AD was measured using QMASS 6.2.1. (Medis, The Netherlands) and a standard equation (AD = ΔD/(ΔP*D); where ΔD is absolute difference in systolic and diastolic volume of the aorta, ΔP the pulse pressure of the artery and D the diastolic arterial volume ).
Both groups improved their AD after six months of aggressive antihypertensive treatment, but there was no statistical difference between the two groups. The post-treatment AD in both hypertensive groups was found to have returned to normal levels when compared to a control group. It therefore appears that the improvement in AD is not treatment specific, but rather occurs as a consequence of lowering BP.
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