- Poster presentation
- Open Access
Myocardial hypoperfusion due to hypoplastic coronary arteries: a cause for false-positive results during adenosine stress Cardiac Magnetic Resonance Imaging
© Pilz et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Coronary Angiography
- Cardiac Magnetic Resonance
- Coronary Stenosis
- Significant Coronary Artery Disease
- Stress Cardiac Magnetic Resonance
Magnetic resonance myocardial perfusion imaging (MRMPI) based on adenosine stress cardiac magnetic resonance (CMR) is increasingly proposed for non-invasive detection of relevant coronary artery disease (CAD). However, little is known about the impact of the normal variability of coronary anatomy and caliber on the diagnostic performance of adenosine stress CMR.
Aim of our study was to examine whether hypoplastic coronary arteries found as normal variations in right-dominant or left-dominant circulation may account for visualization of hypoperfusion in the absence of coronary stenosis and thus may result in false-positive (FP) results of MRMPI in the assessment of CAD.
From 05/2007 until 01/2008, we enrolled 206 consecutive patients with suspected CAD undergoing MRMPI, who were diagnosed as having myocardial ischemia during adenosine-stress perfusion and subsequently underwent coronary angiography (CA). Patients were examined in a 1.5 T whole-body scanner (GE Signa Excite). After three minutes of adenosine infusion (140 μg/kg/min), myocardial first-pass sequence in 4–5 continuous short-axis orientation using Gadolinium-based contrast agent was performed (0.1 mmol/kg, Omniscan, GE Healthcare Buchler). Images were visually analyzed in comparison to rest perfusion by two experienced investigators in consensus. A perfusion deficit was regarded relevant if affecting more than 1/3 of myocardial wall thickness in at least two neighbouring myocardial segments and persisting for more than five heart beats after maximal signal intensity in the LV cavity. Significant CAD was defined as luminal narrowing of ≥70% in CA.
LV EDV (ml)
LV mass (g)
LV wall stress
Transmural extent of ischemia
Temporal persistence of ischemia (beats)
CMR – CA correlation:
Ischemia in area with hypoplastic vessel
Hypoplastic coronary arteries found as normal variations in right-dominant or left-dominant circulation may account for visualization of hypoperfusion in the absence of coronary stenosis and thus may result in false-positive results of MRMPI in the assessment of CAD. Thus, noninvasive asessment of the proximal coronary diameter in the vessel supplying the area of ischemia could reduce the rate of false positive CMR results and the rate of subsequent superfluous diagnostic CA.
This article is published under license to BioMed Central Ltd.