- Poster presentation
- Open Access
Differences in MR perfusion of malignant and benign cardiac tumors
© Bauner et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Maximum Slope
- Cardiac Tumor
- Dynamic Magnetic Resonance Imaging
Primary cardiac tumors are a rare disease while secondary cardiac neoplasms are found more often. The localisation of the tumor, the patient's age and if present, primary malignancy or systemic disease, may give hints to the characterization of a particular cardiac neoplasm. Unenhanced T1- and T2- weighted MR-imaging and fat and suppression techniques allow for comprehensive tissue characterisation. However, additional information can be derived from first pass perfusion imaging and sometimes diagnosis can be made without biopsy and surgery.
To determine whether dynamic contrast material-enhanced magnetic resonance (MR) imaging with use of kinetic parameters reveals statistically significant differences between benign and malignant cardiac tumors.
This study involved 23 patients with cardiac tumors (Myxoma (n = 7), Lipomatous hypertrophy of the interatrial septum (n = 2), Fibroma (n = 1), Rhabdomyoma (n = 2), Angiomyolipoma (n = 1), Angiosarcoma (n = 4), Rhabdomyosarcoma (n = 1), Hemeangiomyosarcoma (n = 1), Myoliposarcoma (n = 2), Lymphoma (n = 1), Metastasis (n = 1). The patients were examined with a T1 weighted turboFLASH sequence. The data were transferred to an external workstation and postprocessing was performed by using software written in-house in IDL 5.4. Contrast enhancement ratios, maximum slope of contrast enhancement ratio curve (% / sec) and the area under the contrast enhancement ratio curve (% * sec) were calculated. Statistical analysis were performed with the unpaired t-test. P values less than 0.05 were considered statistically significant. In addition sensitivities and specificities to differentiate benign from malignant masses were calculated for each parameter and receiver-operator-characteristics (ROC) were assessed.
Dynamic MR imaging delineates significant kinetic differences in perfusion between malignant and benign cardiac tumors. Semiquantitative assessment of perfusion parameters can help to discriminate these by determination of contrast enhancement ratios, calculation of the maximum slope of the CER curve and the area under the CER-curve.
This article is published under license to BioMed Central Ltd.