- Poster presentation
- Open Access
Multi-contrast delayed enhancement imaging (MCDE): accuracy and reproducibility compared to conventional SSFP and delayed hyperenhancement imaging
© Connelly et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Wall Motion
- Cardiac Magnetic Resonance
- Cardiac Magnetic Resonance Imaging
- Inversion Pulse
- Delay Enhancement Imaging
Cardiac magnetic resonance (CMR) imaging is an important tool in the assessment of cardiac function and viability, with prognostic implications for patients with ischemic heart disease . Multi-contrast delayed enhancement imaging (MCDE) allows myocardial viability and wall motion to be assessed simultaneously by producing cardiac-phase-resolved images at multiple inversion times .
This study compared MCDE imaging to the conventional wall motion and viability CMR imaging for the evaluation of ejection fraction (EF), LV mass, LV end-diastolic volume (EDV) and infarct mass.
CMR imaging was well tolerated in all subjects. Images from two patients were excluded from the final analysis as an incorrect placement of the inversion pulse for the MCDE sequence prevented systolic frame identification. Myocardial infarct was detected on delayed enhancement images in 24 patients, with associated wall motion abnormalities and a reduced EF. MCDE, IR-GRE, and SSFP imaging demonstrated excellent correlation for EF, LV infarct size, LV mass and LV EDV (all r>0.9, p < 0.001). Bland-Altman analysis demonstrated excellent agreement in the assessment of EF (bias = -2% (95% CI: -8% to 4%)), LV infarct size (bias = 0.2 g (-1.5 g to 2.0 g)) and LV mass (bias = 0.2 g (-18 g to 18 g)). Agreement was clinically acceptable for LV EDV (bias = -7 mL (-30 mL to 16 mL)). Inter and intra-observer variability was low between SSFP / IR-GRE and MCDE imaging.
MCDE demonstrated excellent clinical agreement with conventional SSFP and IR-GRE imaging in the assessment of cardiac function and viability. MCDE provides wall motion and viability information during a single breath-hold with inherent spatial registration, as opposed to the cine SSFP and IR-GRE acquisitions which require separate breath-holds. MCDE imaging may be considered an alternative to conventional imaging.