- Poster presentation
- Open Access
Myocardial T2* mapping free of distortion using susceptibility weighted spin-echo based imaging: a feasibility study
© Heinrichs et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Blood Oxygen Level Dependent
- Echo Train Length
- Double Inversion Recovery
- Refocus Pulse
- Respiratory Motion Compensation
Myocardial T2* mapping is of proven value for the assessment of myocardial iron content and tissue oxygenation [1, 2]. Conventionally, T2*-weighting is accomplished with gradient echo based or echo planar imaging techniques. However, the disadvantages of T1-related saturation effects, artifacts due to ventricular blood flow and image distortion must be addressed to pave the way for a broader clinical acceptance. Hence, spin-echo based acquisition strategies which generate T2* contrast free of distortion represent a valuable alternative.
This study demonstrates the promise of navigator gated, susceptibility weighted, fast spin-echo imaging in conjunction with ventricular black blood preparation, for anatomically accurate T2* mapping of the heart.
The feasibility and anatomic fidelity of T2*-weighted fast spin echo imaging have been demonstrated together with the image quality advantage over EPI. The proposed susceptibility spin-echo based approach promises to extend the capabilities of CVMR, including mapping and quantification of myocardial iron content, assessment of endothelial function, detection of stress induced angina pectoris, and differentiation of arteries and veins, which have all been elusive hitherto. It also holds the promise to potentially obviating the need for contrast agents for the assessment of myocardial perfusion while avoiding the drawbacks of commonly used EPI and gradient echo based approaches. In conclusion, we anticipate the extension of this work to higher field strengths to maximally exploit the SNR and contrast-to-noise (CNR) advantage and (iii) to evolve towards three-dimensional, distortion free, blood oxygen level dependent (BOLD) imaging of the heart in concert with parallel imaging.
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