- Poster presentation
- Open Access
Assessment of transmural perfusion effect with Blood Oxygen Level-Dependent Cardiovascular Magnetic Resonance Imaging (BOLD-CMR)
© Flewitt et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Cardiovascular Magnetic Resonance
- Coronary Artery Disease Patient
- Coronary Stenosis
- Improve Image Quality
- Suspected Coronary Artery Disease
OLD-CMR has successfully been used for the diagnosis of perfusion deficits caused by coronary stenosis. New BOLD-CMR sequences show improved image quality for assessing myocardial oxygenation with excellent spatial resolution, offering a distinct advantage over other image modalities. We hypothesized that these new BOLD-CMR techniques can detect differences in oxygenation throughout the myocardial wall.
To investigate the epicardial and endocardial oxygenation with a new BOLD-CMR sequence in healthy volunteers compared to patients with suspected coronary artery disease (CAD).
11 healthy volunteers (mean age 29 ± 4 years) and 11 patients with suspected CAD (mean age 59 ± 8 years) who all had abnormal perfusion results on SPECT were recruited for scanning. Using a clinical 1.5 T MRI system (MAGNETOM Avanto, Siemens Healthcare, Erlangen, Germany), SSFP BOLD-CMR was performed on a mid left ventricular short axis slice at baseline and during adenosine infusion (140 micro-g/kg). Typical scan parameters were: Field-of view 193 × 280 mm; matrix size 106 × 192; slice thickness 10 mm; TR/TE 5.8/2.9 ms; flip angle 90°; typical breath-hold duration 14 s. Images were analyzed using clinically validated software (cmr42, Circle Cardiovascular Imaging Inc., Calgary, Canada). After automatic definition of the subendocardial 50% and the subepicardial 50% of the wall thickness, the BOLD signal intensity (SI) for each was analyzed and the relative change from baseline during adenosine infusion was calculated. Late enhancement was performed to ensure that patients did not have an infarct in the selected slice for analysis.
Adenosine induced changes in BOLD SI and HR
SI rel. to baseline whole myocardium
SI rel. to baseline endocardium
SI rel. to baseline epicardium
HR rel. to baseline
Patients with suspected CAD (n = 8)
Healthy volunteers (n = 11)
A state-of-the-art BOLD-sensitive MRI sequence, with its improved image quality and excellent spatial resolution, can detect differences in epicardial and endocardial myocardial oxygenation and are feasible for the clinical setting.
This article is published under license to BioMed Central Ltd.