- Poster presentation
- Open Access
Myocardial vasculature: the third significant contributor to MR diffusion signals in the isolated rabbit heart
© Hwang et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Apparent Diffusion Coefficient
- Slow Component
- Free Wall
- Vascular Space
- Vascular Compartment
The coronary circulation is a significant component of the myocardial mass, due to the high energetic demand of cardiac tissue – the capillary surface area in the heart occupies 14–22% by volume . Thus, vascular spaces need to be considered in addition to interstitial and intracellular spaces for a comprehensive understanding of the physiological compartments responsible for the diffusion signals measured by magnetic resonance. Understanding the origin of MR diffusion signals may reveal changes that precede pathophysiological changes, electrical conductivity and congenital abnormalities, as well as the viability of the cardiac tissue non-invasively.
In this experimental study, we investigated the contribution of the static vasculature to the observed multi-exponential diffusion of water in isolated rabbit heart by replacing the vascular space with perfluorocarbon-emulsion (PFC). We examined the effect of flow by changing the global flow rate of a modified St. Thomas' Hospital cardioplegic solution (STH).
Replacement with the PFC
Change of vascular flow rate
This study demonstrates a significant contribution of vascular compartment to the myocardial MR diffusion characteristics. First, vascular compartment appears to be a significant contributor to the fast component of MR water diffusion. Second, attenuation of signal intensity with b values up to 6500 s/mm2 appears to be modulated by vascular flow.
This article is published under license to BioMed Central Ltd.