Quantification of interventricular dyssynchrony by phase contrast magnetic resonance angiography
© Muellerleile et al; licensee BioMed Central Ltd. 2009
Published: 28 January 2009
Interventricular dyssynchrony is typically assessed by pulsed-wave echocardiography (PW-Echo) as the delay between onset of aortic and pulmonary flow. Recent multicenter trials demonstrated the value of this interventricular dyssychrony to predict response to cardiac resynchronization therapy (CRT). In the present study, the ability of phase contrast magnetic resonance angiography (PC-MRA) was assessed to quantify interventricular dyssynchrony in comparison with PW-Echo.
40 patients with stable heart failure NYHA Class 2 to 3, reduced ejection fraction (28 ± 11%), with (n = 21) or without (n = 19) complete left bundle branch block were prospectively included. Transvalvular flow curves of the aortic and pulmonary valve were acquired by PC-MRA and PW-Echo. Interventricular delay was calculated for PC-MRA as the delay between onset of aortic and pulmonary flow in analogy to PW-Echo. Interventricular delays by PC-MRA were correlated with PW-Echo; agreement was assessed by Bland-Altman analysis.
PC-MRA quantifies interventricular dyssynchrony comparable with PW-Echo. PC-MRA has the potential to identify responders to CRT.
This article is published under license to BioMed Central Ltd.