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Quantification of interventricular dyssynchrony by phase contrast magnetic resonance angiography


Interventricular dyssynchrony is typically assessed by pulsed-wave echocardiography (PW-Echo) as the delay between onset of aortic and pulmonary flow. Recent multicenter trials demonstrated the value of this interventricular dyssychrony to predict response to cardiac resynchronization therapy (CRT). In the present study, the ability of phase contrast magnetic resonance angiography (PC-MRA) was assessed to quantify interventricular dyssynchrony in comparison with PW-Echo.


40 patients with stable heart failure NYHA Class 2 to 3, reduced ejection fraction (28 ± 11%), with (n = 21) or without (n = 19) complete left bundle branch block were prospectively included. Transvalvular flow curves of the aortic and pulmonary valve were acquired by PC-MRA and PW-Echo. Interventricular delay was calculated for PC-MRA as the delay between onset of aortic and pulmonary flow in analogy to PW-Echo. Interventricular delays by PC-MRA were correlated with PW-Echo; agreement was assessed by Bland-Altman analysis.


A strong correlation between interventricular delays by PW-Echo and PC-MRA was found (r = 0.89, P < 0.0001). Bland-Altman analysis demonstrated a good agreement between both methods (Mean difference -6 ± 15 ms). An example of the assessment of interventricular delays by PC-MRA in one patient with (A) and one patient without interventricular dyssynchrony (B) is illustrated by Figure 1. Aortic (red) and pulmonary (blue) valve flow curves are plotted; interventricular delay by PC-MRA was 168 ms in patient A (PW-Echo = 146 ms) and 21 ms in patient B (PW-Echo = 6 ms).

figure 1

Figure 1


PC-MRA quantifies interventricular dyssynchrony comparable with PW-Echo. PC-MRA has the potential to identify responders to CRT.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Muellerleile, K., Baholli, L., Groth, M. et al. Quantification of interventricular dyssynchrony by phase contrast magnetic resonance angiography. J Cardiovasc Magn Reson 11 (Suppl 1), P82 (2009).

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