- Poster presentation
- Open Access
Oxidative stress and inflammatory markers are determinants of carotid artery disease quantified by magnetic resonance imaging
© Dhawan et al; licensee BioMed Central Ltd. 2009
- Published: 28 January 2009
- Magnetic Resonance Image
- Oxidative Stress
- Wall Thickness
Magnetic Resonance Imaging (MRI) can be used to measure common carotid artery maximum wall thickness (CCA-CWT) that incorporates the adventitia to intima-media thickness (IMT). Whether serologic markers of oxidative stress or inflammation are better predictors of wall thickness than conventional risk factors is unknown.
We hypothesized that patients with greater CCA-CWT have higher systemic levels of oxidative stress and inflammation.
CCA-CWT was measured using MRI based T2-weighted black-blood sequence on transaxial slices in 92 subjects (61 ± 9 years) with IMT > 0.65 mm. Markers of oxidative stress included serum glutathione (GSH) and cystine (CySS), which are measures of reduced and oxidized thiols, respectively. Markers of inflammation included high-sensitivity c-reactive protein (HsCRP), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and fibrinogen.
Biomarkers of oxidative stress and inflammation are better predictors of MRI quantified carotid artery disease than conventional risk factors. Whether progression of disease will also be predicted by these markers needs further study.
This article is published under license to BioMed Central Ltd.