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  • Moderated poster presentation
  • Open Access

Relationship of myocardial scar with cardiovascular disease risk factors in the diabetes control and complications trial (DCCT)/epidemiology of diabetes interventions and complications (EDIC) study

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Journal of Cardiovascular Magnetic Resonance201012 (Suppl 1) :M6

  • Published:


  • Left Ventricular Mass
  • Albumin Excretion Rate
  • Myocardial Scar
  • Cardiovascular Disease Risk Factor
  • Abnormal Left Ventricular


Type 1 diabetes is associated with an increased risk of myocardial infarction. Risk factors related to the presence of myocardial scar detected by MRI have not been explored in patients with type 1 diabetes.


To determine the prevalence of myocardial scar and to examine cardiovascular disease (CVD) risk factors associated with myocardial scar in a large multi-center study.


The EDIC study is the observational follow-up (1994-present) of the DCCT cohort. The DCCT (1983-93) was a controlled clinical trial of intensive versus conventional diabetes treatment in 1441 type 1 diabetic subjects. A total of 1019 DCCT/EDIC subjects underwent cardiovascular MRI at 28 centers in the USA and Canada during the 14th year of EDIC. MRI examination, centrally read, included left ventricular (LV) mass, volume and myocardial scar evaluation. A total of 757 eligible patients underwent 15 minute myocardial delayed enhancement MRI following intravenous administration of 0.15 mmol/kg dose of gadolinium contrast. Subjects with gadolinium allergy, dialysis, transplant or GFR < 60 mL/min/1.73 m2 were excluded from the gadolinium study. Images were evaluated for the presence and absence of myocardial scar as well as typical (infarct related) and atypical (non-infarct related) pattern of scar.


743 studies were available for evaluation of myocardial scar (14 non-diagnostic studies). The mean age was 49 ± 7 years, 58% were men, and diabetes duration was 27 ± 5 years. The prevalence of any myocardial scar was 4.3% (32/743) with 16 typical and 16 atypical patterns. Men had a higher prevalence of scar compared to women (5.8% vs. 2.2%, respectively; p < 0.05). Older patients and those with hypertension, lower ejection fraction, increased LV mass and higher albumin excretion rate had a significantly higher risk of myocardial scar than those without. The weighted mean hemoglobin (HbA1c) level was also associated with the presence of myocardial scar, while HbA1c prior to examination was not. Adjusted odds ratios* and 95% confidence intervals for presence versus absence of myocardial scar are shown in Table 1.
Table 1

Adjusted odds ratios* and 95% confidence intervals for presence versus absence of myocardial scar


Adjusted odds ratio*

95% confidence interval

p - value

Males vs. Females


(1.07 - 5.90)


Age (years)


(1.02 - 1.15)


Hypertension (yes vs. no)


(1.20 - 6.36)


Hyperlipidemia (yes vs. no)


(0.80 - 5.09)


LV Mass(g/m2)


(1.01 - 1.06)


EF < 50 (yes vs. no)


(4.17 - 26.88)


Weighted mean HbA1C




Albumin Excretion Rate (AER) > 300 (mg/24 hr)


(1.34 - 10.96)


* All except for gender and age were adjusted for age and gender. Gender was adjusted for age, age was adjusted for gender.


The DCCT/EDIC is the first and largest cohort of type 1 diabetic patients evaluated by MRI for myocardial scar. Overall, the prevalence of myocardial scar in DCCT/EDIC was 4.3%. Traditional CVD risk factors (age, gender and hypertension) as well as abnormal LV mass and function, weighted mean HbA1c levels and macroalbuminuria were risk factors for myocardial scar in this multi-center cohort with type 1 diabetes.

Authors’ Affiliations

NIH, Bethesda, MD, USA
George Washington University, Rockville, MD, USA
Massachusetts General Hospital, Boston, MA, USA
Leiden University Medical Center, Leiden, Netherlands
Johns Hopkins University, Baltimore, MD, USA


© Turkbey et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.