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Whole-heart magnetic resonance imaging for visualization of venous anatomy and myocardial scar using slow infusion of Gd-BOPTA in single exam
Journal of Cardiovascular Magnetic Resonance volume 12, Article number: O21 (2010)
For cardiac resynchronization therapy (CRT), knowledge of the coronary venous anatomy in relation to areas of myocardial scar is important to plan the optimal LV lead position during the CRT-procedure. Cardiac magnetic resonance imaging (CMR) has previously been used to assess coronary veins without a contrast agent (CA) using MTC-prepulse or injecting an intravascular CA. However, neither of these methods provide information about myocardial scar.
In this work we investigated a CMR-examination with slow infusion of a high relaxivity CA to evaluate visualization of coronary venous anatomy and myocardial scar in heart failure patients.
Twelve patients with known left ventricular (LV) impairment (6 with and 6 without ischemic cardiomyopathy) and two patients with normal LV function underwent CMR on a 1.5 T Philips scanner (12 men; 2 women age 59.5 ± 15.5 yrs). For vein visualization, an ECG-triggered respiratory navigated 3D SSFP MR-scan (FA = 50, 1.5 × 1.5 × 2 mm) with Inversion recovery (IR) preparation (TI = 300 ms) was used to acquire the whole-heart during a short interval (60-80 ms) in end systole. For contrast enhancement dimeglumine-gadobenate (Gd-BOPTA) was slowly infused (dose of 0.2 mls/kg at rate 0.3 mls/sec) with subsequent saline flushing as proposed by Bi et al (MRM 2007 58:1-7) for coronary arteries. In order to determine the optimal start point of the 3D IR-SSFP scan, a dynamic ECG-triggered IR-scan was used to measure bolus arrival in the LV(Figure 1). A multislice delayed contrast-enhanced MR-scan (1.5 × 2 × 10 mm) was performed at end systole 19 ± 7 min after start of contrast injection to depict areas of scar.
In all subjects the coronary sinus (CS) and great cardiac vein (GCV) were visualized (figure 2). Two experienced independent observers assessed the image quality (0 to 4). The average score for the CS was 3.1 ± 0.97 (r = 0.89) and GCV 2.6 ± 0.63 (r = 0.74) and excellent correlation between number of vessels seen by both observers (r = 0.98) (table 1). The posterior interventricular (PIV) and lateral marginal vein (LMV) were seen in 11 patients (79%), posterior vein of the LV (PVLV) in 6 patients (43%) and the anterior interventricular vein (AIV) in 10 patients (71%). The mean distance from the ostium of the CS to the PIV was 12.6 ± 4.0 mm, LMV was 68.3 ± 20.3 mm, PVLV 32.2 ± 19.3 mm and AIV was 142.5 ± 20.5 mm (table 2) (figure 3). Patients with ischemic cardiomyopathy showed late enhancement.
We have demonstrated that slow infusion protocol of Gd-BOPTA can be used to assess both the coronary venous anatomy and myocardial scar in a single MR-examination.
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Duckett, S.G., Ginks, M., Knowles, B.R. et al. Whole-heart magnetic resonance imaging for visualization of venous anatomy and myocardial scar using slow infusion of Gd-BOPTA in single exam. J Cardiovasc Magn Reson 12 (Suppl 1), O21 (2010). https://doi.org/10.1186/1532-429X-12-S1-O21
- Cardiac Magnetic Resonance
- Cardiac Resynchronization Therapy
- Coronary Sinus
- Myocardial Scar
- Left Ventricular Lead