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Whole-heart magnetic resonance imaging for visualization of venous anatomy and myocardial scar using slow infusion of Gd-BOPTA in single exam


For cardiac resynchronization therapy (CRT), knowledge of the coronary venous anatomy in relation to areas of myocardial scar is important to plan the optimal LV lead position during the CRT-procedure. Cardiac magnetic resonance imaging (CMR) has previously been used to assess coronary veins without a contrast agent (CA) using MTC-prepulse or injecting an intravascular CA. However, neither of these methods provide information about myocardial scar.


In this work we investigated a CMR-examination with slow infusion of a high relaxivity CA to evaluate visualization of coronary venous anatomy and myocardial scar in heart failure patients.


Twelve patients with known left ventricular (LV) impairment (6 with and 6 without ischemic cardiomyopathy) and two patients with normal LV function underwent CMR on a 1.5 T Philips scanner (12 men; 2 women age 59.5 ± 15.5 yrs). For vein visualization, an ECG-triggered respiratory navigated 3D SSFP MR-scan (FA = 50, 1.5 × 1.5 × 2 mm) with Inversion recovery (IR) preparation (TI = 300 ms) was used to acquire the whole-heart during a short interval (60-80 ms) in end systole. For contrast enhancement dimeglumine-gadobenate (Gd-BOPTA) was slowly infused (dose of 0.2 mls/kg at rate 0.3 mls/sec) with subsequent saline flushing as proposed by Bi et al (MRM 2007 58:1-7) for coronary arteries. In order to determine the optimal start point of the 3D IR-SSFP scan, a dynamic ECG-triggered IR-scan was used to measure bolus arrival in the LV(Figure 1). A multislice delayed contrast-enhanced MR-scan (1.5 × 2 × 10 mm) was performed at end systole 19 ± 7 min after start of contrast injection to depict areas of scar.

Figure 1
figure 1

Showing the difference in time taken for contrast agent to reach the left ventricle in patients with normal and imparted LV function. The bolus track sequence allows optimization of timing of the whole heart scan.


In all subjects the coronary sinus (CS) and great cardiac vein (GCV) were visualized (figure 2). Two experienced independent observers assessed the image quality (0 to 4). The average score for the CS was 3.1 ± 0.97 (r = 0.89) and GCV 2.6 ± 0.63 (r = 0.74) and excellent correlation between number of vessels seen by both observers (r = 0.98) (table 1). The posterior interventricular (PIV) and lateral marginal vein (LMV) were seen in 11 patients (79%), posterior vein of the LV (PVLV) in 6 patients (43%) and the anterior interventricular vein (AIV) in 10 patients (71%). The mean distance from the ostium of the CS to the PIV was 12.6 ± 4.0 mm, LMV was 68.3 ± 20.3 mm, PVLV 32.2 ± 19.3 mm and AIV was 142.5 ± 20.5 mm (table 2) (figure 3). Patients with ischemic cardiomyopathy showed late enhancement.

Figure 2
figure 2

A and B show the coronary sinus (CS) and great cardiac vein (GCV) with the posterior lateral vein on the LV (PVLV) on multiplanar reformatted images (mpr). C is a mpr formatted image showing the extent of the coronary vein from the CS to the anterior inter-ventricular (AIV) tributary. D shows a three dimensional recontruction of the coronary venous system with the various brances. E and F show late enhancement in the inferior territory. LV = Left ventricle, LA = Left atrium, RV - Right ventricle, RA = Right atrium.

Figure 3
figure 3

A shows a 3D reconstruction with 2 saphenous ven grafts (SVG) and the anterior inter-ventricular branch of the coronary venous system. B shows the measuremewnt of the vessel from the CS to the origin of the lateral marginal vein (LMV) and the length down the vessel. C shows the angle the LMV makes with the coronary vein. D shows the measurement of the diameter of the CS in various planes. LV = Left ventricle, LA = Left atrium

Table 1 Anatomical observations and percentage of vessels seen by both observers
Table 2 Ostial diameter in multiplanar reformatting views and visible length of the identified veins


We have demonstrated that slow infusion protocol of Gd-BOPTA can be used to assess both the coronary venous anatomy and myocardial scar in a single MR-examination.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Duckett, S.G., Ginks, M., Knowles, B.R. et al. Whole-heart magnetic resonance imaging for visualization of venous anatomy and myocardial scar using slow infusion of Gd-BOPTA in single exam. J Cardiovasc Magn Reson 12 (Suppl 1), O21 (2010).

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