- Oral presentation
- Open Access
Optimising the accuracy and reproducibility of aortic root measurements from cardiac MRI data
© Mortensen et al; licensee BioMed Central Ltd. 2010
- Published: 21 January 2010
- Aortic Root
- Turner Syndrome
- Bicuspid Aortic Valve
- Marfan Syndrome
- True FISP
Paediatric aortopathy is assessed increasingly with MRI, because 3D data is acquired without ionising radiation, which is advantageous for serial assessment. However, the accuracy and repeatability of aortic measurements are limited because no consistency exists regarding measurement positions and technique
To investigate the best possible reproducibility of paediatric aortic measurements, using different MR sequences and post-processing, with a single, experienced observer
Bland-Altman analyses of aortic size measurements obtained by different techniques and from different MRI sequences in paediatric aortopathy (N = 20).
OF REPEAT 3D MEASUREMENTS
(one week in between)
DIFFERENCE between 3D PERPENDICULAR and 2D CINE
2D CINE IMAGING
Mean difference % [95%CI]
In paediatric ascending aortopathy, even with a single, experienced observer measuring the same raw data and using consistent measurement technique, there is considerable error associated with assessment of aortic root size, comparing different techniques and repeat measurements. Our results indicate that even with optimal 3D imaging and systematic post-processing, there is clinically important variability. This would be compounded further by interobserver variability, inconsistent slice planning on 2D cine imaging, varying leaflet configuration, asymmetric dilatation and patient growth. Therefore, accurate and clinically valid serial assessment of paediatric aortopathy crucially requires standardisation of scanning and post-processing techniques. This data highlights the issues and suggests appropriate measurement parameters.
Maximum aortic diameter at sinus level is cusp-to-commisure.
Aortopathies: Marfan syndrome (6), Loeys-Dietz syndrome (1), Turner syndrome (2), bicuspid aortic valve (4), and other connective tissue disease (7).
This article is published under license to BioMed Central Ltd.