- Oral presentation
- Open Access
Spin-spoiler: a novel arterial spin labeling technique without the need of subtraction
© Andia and Botnar; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Arterial Spin Labeling (ASL) has been successfully used for the visualization of the renal and coronary arteries without the need of a contrast agent [1, 2]. The classical approach of ASL consists of the acquisition of two image datasets with and without a spatially selective labeling prepulse. The disadvantages of this methodology include the need for two acquisitions and image subtraction resulting in increased sensitivity to motion. Alternative techniques not requiring image subtraction have been proposed and successfully applied for renal and coronary angiography . In this work we propose a novel ASL technique (Spin-Spoiler) without the need for image subtraction. It is based on the application of a spatially selective labeling pulse followed by a non-selective refocusing and a tip up pulse resulting in localized spin tagging and simultaneous background tissue suppression over a wide range of T1 values. We sought to evaluate this technique in a T1 phantom and in healthy subjects for selective renal artery visualization.
The Spin-Spoiler technique was validated in a T1-phantom and selective angiography was demonstrated for the renal arteries.
We demonstrate a new approach for non-contrast enhanced MR angiography with good background tissue suppression without the need of subtraction. Comparative studies are now warranted to demonstrate the clinical usefulness of this technique.
This article is published under license to BioMed Central Ltd.