- Oral presentation
- Open Access
Simultaneous acquisition of MRI and PET cardiac cine 3D images at 9.4 Tesla
© Smith et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Nuclear medicine imaging techniques, such as Positron Emission Tomography (PET) can provide important functional information helpful to the assessment of cardiovascular health. The limitations in resolution and anatomical detail for the PET images can be overcome by superposition on a companion high resolution MR image, if an accurate co-registration of the PET and MR images is made.
A 25 gram male Swiss/Webster mouse was anesthesized with an initial injection of nembutol in preparation for imaging in the combined MR/PET system. A tail vein catheterization was inserted for the purpose of administering a 300 micro-Curie bolus of mCi 18F-FDG positron emitter. The isotope was injected 30 minutes prior to the start of data acquisition. Both three dimensional (volume) and two dimensional (oblique slice) MR images were acquired using an ECG triggered 10 frame FLASH cine imaging sequence (TE 2.7 msec TR 10 msec). The PET data acquisition system was operational and continuously accumulated coincidence data during the entire MR imaging period. The PET acquisition system was configured to record the ECG gate timing data.
We have demonstrated that dynamic PET and MR images can be acquired simultaneously, allowing precise co-registration of the two image types. This can greatly assist the interpretation of the PET image data and may allow correlation to fine structural changes observable in the MR images. Future studies will compare results using alternative isotopes and delivery systems.
This article is published under license to BioMed Central Ltd.