- Oral presentation
- Open Access
An MRI examination for evaluation of aortic dissection using a blood pool agent
© Clough et al; licensee BioMed Central Ltd. 2010
- Published: 21 January 2010
- Aortic Dissection
- Blood Pool
- False Lumen
- Blood Pool Imaging
- Regurgitant Flow
In aortic dissection the formation of thrombus in the false lumen is associated with improved survival. . Current imaging using contrast-enhanced computed tomography (CT) assumes the presence of thrombus by the absence of contrast but due to altered flow this finding may not be accurate.
The aims of this study were to i) investigate the use of direct thrombus MRI together with 3D MRA using a blood pool agent to quantify false lumen thrombus volume in patients with Type B aortic dissection, and ii) compare the volumes to those obtained by clinical CT.
Analysis was feasible in all ten patients. Flow evaluation in the true and false lumen showed altered and regurgitant flow. The thrombus volumes derived from first pass 3D CE MRA and CT were significantly greater than those obtained with blood pool imaging. The mean difference between first pass 3D CE MRA and blood pool imaging was 114.4 cm3 ((95%CI 60.04-168.7), p = 0.001), and between CT and blood pool imaging was 69.97 cm3 ((95%CI 14.33-125.60), p = 0.019). Thrombus location and morphology was confirmed by direct thrombus MRI in all patients.
Blood pool imaging together with direct thrombus MRI allows assessment of aortic anatomy and quantification of false lumen thrombosis. Current clinical trials using false lumen thrombosis as a primary endpoint should consider multi-parametric MRI as the preferred diagnostic tool.