Long-term prognostic significance of late gadolinium enhancement in non-ischemic dilated cardiomyopathy: further evidence from 184 patients
© Lehrke et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Non-ischemic dilated cardiomyopathy (DCM) is a major cause for cardiovascular morbidity and premature mortality. Due to the variable clinical course, risk stratification is of paramount importance in these patients to identify those most likely to benefit from aggressive treatment strategies. There is emerging evidence for the prognostic significance of late gadolinium enhancement (LGE) in patients with DCM.
The goal of this study was to further investigate the long-term prognostic significance of LGE in a large cohort of patients with DCM presenting to a tertiary referral center.
Contrast-enhanced cardiovascular magnetic resonance (CE-CMR) was performed in 184 consecutive patients with DCM on a 1.5 T clinical scanner. Significant coronary artery disease had been ruled out in all patients. LV volumes and mass were derived from SSFP cine images. Presence of LGE was determined by two independent observers. Patients were followed for the primary endpoint of cardiac death and a composite endpoint of cardiac death, hospitalization for decompensated heart failure or appropriate ICD firing for a mean of 685 ± 30 days.
Predictors of the composite endpoint by Cox regression
HR (95% CI)
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