- Oral presentation
- Open Access
Obesity and right ventricular structure and function: the MESA-RV study
© Chahal et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
The relationship between obesity and right ventricle (RV) has been inadequately studied due to difficulty in imaging its more complex geometry by echocardiography. While obesity associated RV diastolic dysfunction has been shown, inconclusive data exists regarding systolic function. We aimed to determine the association between obesity and RV structure and function by cardiac magnetic resonance imaging (MRI) in a large multi-ethnic cohort.
We hypothesized that obesity would be associated with greater RV mass, larger RV end-diastolic volume (EDV), and lower RV ejection fraction (EF).
Cardiac MRIs were analyzed from 1973 participants in the Multi-Ethnic Study of Atherosclerosis, which included individuals aged 45-84 years without clinical cardiovascular disease. Participants were divided into 3 categories based on BMI: normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) and obese (= 30 kg/m2). Associations with RV measures were determined using multivariable regression.
In a cohort free of clinical cardiovascular disease, obesity was significantly associated with higher RV mass, RVEDV and lower RVEF even after adjustment for the LV. Future studies should examine the mechanism of this effect on the RV.
This article is published under license to BioMed Central Ltd.