Comparison of myocardial scar quantification using phase sensitive inversion recovery (PSIR) versus conventional IR-tLF techniques in patients with ischemic and non-ischemic cardiomyopathy
© Warren et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Delayed enhancement (DE) CMR affords quantitative evaluation of myocardial scar in ischemic and non-ischemic populations. Phase correction (PC) of DE optimizes signal intensity differences between normal and abnormal myocardium. However, limited data exists validating it's quantitative assessment of scar using signal thresholding techniques.
To compare scar quantification using PC and un-corrected (UC) DE imaging in a large series of patients.
Imaging was performed using a 1.5 T or 3 T Siemens scanner in patients with known or suspected cardiomyopathy. Serial short axis DE imaging was performed using a PSIR-tFL pulse sequence with the TI time adjusted to optimally null normal myocardium on magnitude images. Semi-automated scar volumes were calculated for matched PC and UC-DE images at 2, 3 and 5 standard deviation (SD) above normal myocardium and compared using a two tailed paired-sample Student's t- test. Pearson correlation coefficients were calculated and linear regression analysis performed for PC versus UC methods. Scar border-zone was calculated for the ischemic sub-group using the difference between 3 and 5 SD thresholds and compared in the same fashion.
Phase correction of DE images results in significant reductions in quantitative scar volumes at all measured signal thresholds. Quantification of ischemic scar border-zone is similarly reduced using the PSIR sequence due to relatively larger reductions in scar volumes at the lower SD threshold.
This article is published under license to BioMed Central Ltd.